| 急性心肌梗死患者外周血CD34+细胞与肌酸激酶同工酶、N末端B型利钠肽原、左室射血分数的相关性 |
| |
| 引用本文： | 高海英,曲鹏. 急性心肌梗死患者外周血CD34+细胞与肌酸激酶同工酶、N末端B型利钠肽原、左室射血分数的相关性[J]. 中国组织工程研究与临床康复, 2011, 15(23). DOI: 10.3969/j.issn.1673-8225.2011.23.040 |
| |
| 作者姓名： | 高海英 曲鹏 |
| |
| 作者单位： | 1. 大连医科大学附属二院综合一病房,辽宁省大连市,116027
2. 大连医科大学附属二院心内科,辽宁省大连市,116027 |
| |
| 摘 要： | 背景:急性心肌梗死后具有动员骨髓和外周血中的CD34+干细胞的潜能,参与坏死心肌的自身修复,但外周血CD34+细胞与其他相关指标的关系尚不明确,目的:观察急性心肌梗死患者外周血单个核CD34+细胞的动态变化规律,并进一步分析其与肌酸激酶同工酶、N末端B型利钠肽原、左室射血分数的相关性.方法:采集急性心肌梗死患者(实验组)发病第2,3,4,5,7,30,90,120天的外周静脉血及入院后相应时间点非冠状动脉粥样硬化性心脏病患者(对照组)外周静脉血,采用流式细胞仪测定外周血单个核细胞CD34+的百分率.同时对心肌梗死患者进行肌酸激酶同工酶、N末端B型利钠肽原及心脏超声检测.结果与结论:①实验组单个核细胞CD34+细胞百分率于心肌梗死后第3天开始升高,第4天达到高峰,第90天回降至基线水平.对照组单个核细胞CD34+细胞百分率无明显变化.②实验组外周血单个核CD34+细胞与左室射血分数呈正相关关系,与N末端B型利钠肽原呈负相关关系;与肌酸激酶同工酶无相关性.提示急性心肌梗死后4~8 d内给予干细胞治疗可适度改善心脏收缩功能,并且较高的CD34+干细胞表达有益于急性心肌梗死后心肌功能的恢复.
|
| 关 键 词： | 急性心肌梗死 外周血CD34+细胞 肌酸激酶同工酶 左室射血分数 N末端B型利钠肽原 |
Correlation of peripheral blood CD34-positive cells with creatine kinase MB, N-terminal pro-B-type natriuretic peptide, and left ventricular ejection fraction in patients with acute myocardial infarction |
| |
| Gao Hai-ying,Qu Peng. Correlation of peripheral blood CD34-positive cells with creatine kinase MB, N-terminal pro-B-type natriuretic peptide, and left ventricular ejection fraction in patients with acute myocardial infarction[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(23). DOI: 10.3969/j.issn.1673-8225.2011.23.040 |
| |
| Authors: | Gao Hai-ying Qu Peng |
| |
| Affiliation: | Gao Hai-ying1,Qu Peng2 1Department of Internal Medicine,2Department of Cardiology,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,Liaoning Province,China |
| |
| Abstract: | BACKGROUND:Some studies had showed the potential of self-mobilization of CD34 positive stem cells in peripheral blood after acute myocardial infarction.Population remain poorly known about the correlation between the number of CD34 positive stem cells mobilized into peripheral blood,left ventricular ejection fraction(LVEF) ,N-terminal pro-B-type natriuretic peptide(NT-proBNP) levels,and myocardial necrosis markers in patients with acute myocardial infarction(AMI) .OBJECTIVE:To assess the spontaneous express... |
| |
| Keywords: | |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
