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| 冬梅饮对早期糖尿病肾病肾组织基质金属蛋白降解酶-9作用的实验研究 | |
| 引用本文： | 周雪梅,陈雪功,傅裕,王望九,胡建鹏,董昌武,王建青,程维克. 冬梅饮对早期糖尿病肾病肾组织基质金属蛋白降解酶-9作用的实验研究[J]. 中国中医基础医学杂志, 2010, 0(3) |
| 作者姓名： | 周雪梅 陈雪功 傅裕 王望九 胡建鹏 董昌武 王建青 程维克 |
| 作者单位： | 安徽中医学院;安徽滁州市中西医结合医院; |
| 基金项目： | 安徽省教育厅自然科学研究资助项目(2006KJ095C) |
| 摘 要： | 目的:评价中药冬梅饮对早期糖尿病肾病(DN)大鼠肾组织基质金属蛋白酶-9(MMP-9)的影响,探讨其防治早期DN的作用机制。方法:用链尿佐菌素建立早期DN模型,观察冬梅饮对早期DN大鼠血糖、尿β2-MG、肾组织MMP-9的影响。结果:冬梅饮治疗组可升高模型大鼠肾组织MMP-9含量增加(P0.05);降低24h尿β2-MG排泄率(P0.05)。结论:冬梅饮对肾脏具有保护作用,可延缓DN的发展。 |
| 关 键 词： | 糖尿病肾病 冬梅饮 基质金属蛋白酶-9 |
Effects of Dong Mei Decoction on Matrix Metalloproteinases-9 in Kidney Tissues of Early Diabetic Nephropathy |
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| ZHOU Xue-mei,CHEN Xue-gong,Fu Yu,WANG Wang-jiu,HU Jian-peng,DONG Chang-wu,WANG Jian-qing,CHENG Wei-ke. Effects of Dong Mei Decoction on Matrix Metalloproteinases-9 in Kidney Tissues of Early Diabetic Nephropathy[J]. Chinese Journal of Basic Medicine In Traditional Chinese Medicine, 2010, 0(3) | |
| Authors: | ZHOU Xue-mei CHEN Xue-gong Fu Yu WANG Wang-jiu HU Jian-peng DONG Chang-wu WANG Jian-qing CHENG Wei-ke |
| Affiliation: | ZHOU Xue-mei1,CHEN Xue-gong1,Fu Yu2,WANG Wang-jiu1,HU Jian-peng1,DONG Chang-wu1,WANG Jian-qing1,CHENG Wei-ke1 (1. Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China,2. Anhui Chuzhou Cooperation of Chinese , Western medicine hospital,Anhui Chuzhou 239000,China) |
| Abstract: | Object: To evaluate the effects of DongMeiYin(DMY) on Matrix Metallo Proteinase-9 (MMP-9)in the diabetic rats,and to investigate the mechanism of DMY in preventing and treating early diabetic nephropathy(DN).Methods: The rat early DN models were induced by injection streptozotocin (STZ).The model rats were randomly divided into the model group,DMY group,Valsartan group.The course of treatment continued 8 weeks.Observing the changes of MMP-9 in the renal cortex.Results: Compared with the normal group,the lev... |
| Keywords: | diabetic nephropathy DongMeiYin Matrix Metallo Proteinase-9 |
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