稳心颗粒联合决奈达隆治疗老年阵发性房颤的疗效观察

目的 探讨稳心颗粒联合盐酸决奈达隆片治疗老年阵发性房颤的临床疗效。方法 选取2018年11月-2020年1月在开封市人民医院治疗的108例老年阵发性房颤患者为研究对象，按照随机数字表法将所有患者分为对照组和治疗组，每组各54例。对照组口服盐酸决奈达隆片，1片/次，2次/d。治疗组在对照组治疗基础上口服稳心颗粒，1袋/次，3次/d。两组患者均连续治疗6个月。观察两组的临床疗效，比较两组的房颤发作、心率情况、心功能指标和不良反应情况。结果 治疗后，对照组总有效率为74.07%，治疗组总有效率为90.74%，差异有统计学意义（P<0.05）。治疗后，两组房颤发作次数、静息心率显著降低，房颤持续时间显著缩短（P<0.05）；但治疗组改善的更多，差异有统计学意义（P<0.05）。治疗后，两组患者左室射血分数（LVEF）显著升高，左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）、P波离散度（Pd）均显著下降（P<0.05）；但治疗组心功能指标改善更多，差异有统计学意义（P<0.05）。治疗后，对照组不良反应发生率为27.78%，治疗组不良反应发生率为5.56%，差异有统计学意义（P<0.05）。结论 稳心颗粒联合盐酸决奈达隆片治疗老年阵发性房颤具有较好的临床疗效，能够降低房颤发作和心率，显著改善患者心功能，安全性好。

Clinical observation of Wenxin Granules combined with dronedarone in treatment of paroxysmal atrial fibrillation in the elderly

Objective To explore the clinical efficacy of Wenxin Granules combined with Dronedarone Hydrochloride Tablets in treatment of paroxysmal atrial fibrillation in the elderly. Methods Elderly patients (104 cases) with paroxysmal atrial fibrillation in Kaifeng People''s Hospital from November 2018 to January 2020 were randomly divided into control and treatment groups, and each group had 54 cases. Patients in the control group were po administered with Dronedarone Hydrochloride Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Wenxin Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacies were evaluated, and atrial fibrillation attack, heart rate, cardiac function indexes, and adverse reactions in two groups were compared. Results After treatment, the total effective rate of the control group was 74.07%, that of the treatment group was 90.74%, and the difference was statistically significant (P<0.05). After treatment, the frequency of atrial fibrillation and the heart rate in two groups were significantly reduced, and the duration of atrial fibrillation in two groups was significantly shortened (P<0.05); and the indexes of the treatment group were better than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the LVEF in two groups was significantly increased, but the LVEDD, LVESD, and Pd in two groups were significantly decreased (P<0.05). And the cardiac function indexes in the treatment group were better than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the incidence of adverse reactions in the control and treatment groups were 27.78% and 5.56%, respectively, and the difference was statistically significant (P<0.05). Conclusion Wenxin Granules combined with Dronedarone Hydrochloride Tablets has clinical curative effect in treatment of paroxysmal atrial fibrillation in the elderly, can reduce atrial fibrillation attack and heart rate, and significantly improve the heart function of patients with good safety.