| 脑源性神经营养因子在抑郁症中的研究进展 |
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| 引用本文： | 王思琪,苏静,马世平,傅强.脑源性神经营养因子在抑郁症中的研究进展[J].江苏药学与临床研究,2020,28(4):279-282. |
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| 作者姓名： | 王思琪 苏静 马世平 傅强 |
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| 作者单位： | 中国药科大学,中国药科大学,中国药科大学,中国药科大学 |
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| 基金项目： | 国家自然科学基金面上项目（81573701） |
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| 摘 要： | 脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）是参与机体情绪和认知功能至关重要的调节因子，能够促进脑内神经发生和突触发育。在抑郁患者及抑郁动物模型中，BDNF前体（brain-derived neurotrophic factor precursor，proBDNF）和前肽水平升高，BDNF成熟体（mature brain-derived neurotrophic factor，mBDNF）水平降低；抗抑郁药物治疗后，能够抑制proBDNF以及BDNF前肽的表达，促进mBDNF/proBDNF蛋白比值的升高。目前临床常见抗抑郁药的抗抑郁作用多依赖于BDNF及相关蛋白的信号转导。本文通过查阅文献，对BDNF及其相关因子在抑郁症中的作用进行总结。
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| 关 键 词： | 抑郁症 脑源性神经营养因子 脑源性神经营养因子前体 |
| 收稿时间： | 2020/5/25 0:00:00 |
| 修稿时间： | 2020/6/30 0:00:00 |
Research Progress of Brain-derived Neurotrophic Factor in Depression |
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| Siqi Wang,Jing Su,Shiping Ma and Qiang Fu.Research Progress of Brain-derived Neurotrophic Factor in Depression[J].Jiangsu Pharmacertical and Clinical Research,2020,28(4):279-282. |
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| Authors: | Siqi Wang Jing Su Shiping Ma and Qiang Fu |
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| Institution: | China Pharmaceutical University,China Pharmaceutical University,China Pharmaceutical University,China Pharmaceutical University |
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| Abstract: | Brain-derived neurotrophic factor (BDNF) is a critical regulator of body emotional and cognitive function promoting neurogenesis and synaptic development. Levels of proBDNF and BDNF pro-peptide were elevated in depressive patients and animal models, and the level of mBDNF was decreased. Antidepressants treatment suppressed proBDNF and BDNF pro-peptide expressions and promoted a raise of mBDNF/proBDNF ratio. The antidepressant effects of current common clinical antidepressants were mostly dependent on the signal transduction of BDNF and related proteins. This paper then reviewed the literature to summarize the effects of BDNF and its related factors in depression. |
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| Keywords: | Depression BDNF proBDNF |
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