HIV-1 tropism evolution after short-term maraviroc monotherapy in HIV-1-infected patients期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

HIV-1 tropism evolution after short-term maraviroc monotherapy in HIV-1-infected patients

Authors:	Gonzalez-Serna Alejandro Romero-Sánchez María Concepción Ferrando-Martinez Sara Genebat Miguel Vidal Francesc Muñoz-Fernández Maria Ángeles Abad María Antonia Leal Manuel Ruiz-Mateos Ezequiel

Affiliation:	Laboratorio de Inmunovirologia, Servicio Enfermedades Infecciosas, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.

Abstract:	We analyzed the evolution of viral tropism after 8 days of maraviroc monotherapy, i.e., we used the maraviroc clinical test (MCT), in 21 patients with and 14 without virological response to the drug (MCT(+) and MCT(-) patients, respectively). No increases in CXCR4 inferred viral loads (X4IVLs) were observed in MCT(+) patients, while X4IVLs increased only in MCT(-) patients, with X4IVLs of >2 log(10) HIV RNA copies/ml. These results shed light on the evolution of viral tropism under a CCR5 antagonist in vivo.

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