孕妇乙型肝炎病毒感染状态与胎儿宫内感染的关系

目的 :探讨孕妇乙型肝炎病毒 (HBV)感染状态与胎儿宫内感染发生率的关系。方法 :用酶联免疫吸附试验(ELISA)筛选出 79例HBV感染孕妇 ,并用荧光定量聚合酶链反应 (FQ PCR)技术检测孕妇血清及脐血中HBV DNA。结果 :4 7例大三阳孕妇血清HBV DNA检出率为 97 9% ,32例小三阳孕妇血清HBV DNA检出率为 9 4 % ,两组差异有非常显著性 (P <0 0 1)。大三阳孕妇脐血中HBV DNA检出率为 31 9% ,小三阳孕妇脐血中HBV DNA检出率为 0 % ,两组差异有非常显著性 (P <0 0 1)。结论 :胎儿宫内感染与孕妇HBV感染状态和HBV DNA检出率有关。

The Relationship between HBV Infectious Status in Pregnant Women and Intrauterine Infection of Fetus

Objective: To study the relationship of hepatitis B virus (HBV) infectious status in pregnant women to intrauterine fetal infective rate. Methods: 79 pregnant women were detected HBV by ELISA. Maternal serum and cord blood were tested for HBV-DNA with fluorescence quantitative PCR (FQ-PCR). Results: The HBV-DNA-positive rate in maternal serum and cord blood in 47 pregnant women with positive HBsAg, HBeAg, and anti-HBc were 97.9% and 31.9%, respectively. The HBV-DNA-positive rate in maternal serum and cord blood in 32 pregnant women with positive HBsAg, anti-HBe, and anti-HBc were 9.4% and 0, respectively. There was a significant difference between two groups (P<0.01). Conclusions: There is a relationship between the HBV infectious status and HBV-DNA-positive rate in pregnant women and intrauterine fetal infection.