| 稀土复合固体超强酸SO4^2-／ZrO2-CeO2催化合成冰片 |
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| 引用本文： | 刘永根,吴良,李海霞.稀土复合固体超强酸SO4^2-／ZrO2-CeO2催化合成冰片[J].海南医学院学报,2009,15(4):301-302. |
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| 作者姓名： | 刘永根 吴良 李海霞 |
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| 作者单位： | 海南医学院药学系,海南,海口,571101 |
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| 摘 要： | 目的：研究一种合成冰片的新方法。方法：在纳米稀土复合固体超强酸SO4^2-／ZrO2-CeO2催化下，通过α-蒎烯与无水草酸酯化-皂化法合成冰片。结果：酯化反应能顺利进行生成草酸冰片酯，草酸冰片酯并口NaOH发生皂化反应后得到冰片。当酯化反应的温度为80℃，反应时间为6h，催化剂的用量为α-蒎烯质量的6％时，冰片的产率为68．7％，产品中正、异冰片含量比约为5：1。结论：该合成方法具有反应条件温和，污染小，产率高，产品质量好等优点。
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| 关 键 词： | 稀土复合固体超强酸 SO42-/ZrO2-CeO2 酯化-皂化法 α-蒎烯 冰片 |
Synthesis of oborneol catalyzed by rare earth composite solid superacid SO42-/ZrO2 -CeO2 |
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| LIU Yong-gen,WU Liang,LI Hai-xia.Synthesis of oborneol catalyzed by rare earth composite solid superacid SO42-/ZrO2 -CeO2[J].Journal of Hainan Medical College,2009,15(4):301-302. |
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| Authors: | LIU Yong-gen WU Liang LI Hai-xia |
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| Institution: | LIU Yong-gen,WU Liang,LI Hai-xia(Departement of Pharmacy,Hainan Medical College Haikou 571101,China) |
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| Abstract: | Objective: To find a new way of synthesizing borneol.Methods: Trying to synthesize borneol from a-pinene and anhydrous oxalic acid by esterification-saponification under the catalysis of rare earth composite solid superacid S2O82-/ZrO2-CeO2.Results: Reaction of a-pinene and anhydrous oxalic acid afforded bornyl oxalate smoothly and borneol was obtained from bornyl oxalate by saponification with NaOH solution.After 6h reaction in presence of catalyst weighed 6% of the mass of a-pinene,the yield of borneol co... |
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| Keywords: | SO42-/ZrO2-CeO2 |
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