酒精对垂体后叶素致大鼠急性心肌缺血的影响

目的探讨不同剂量酒精对垂体后叶素致大鼠急性心肌缺血的影响。方法 40只健康雄性SD大鼠随机分为5组,即模型对照组(1U/kg垂体后叶素)、阳性对照组(1mg/kg维拉帕米)、5%酒精组(0.4g/kg)、10%酒精组(0.8g/kg)和20%酒精组(1.6g/kg)。大鼠麻醉后舌下静脉注射生理盐水(模型对照组)、维拉帕米1mg/kg(阳性对照组)和酒精0.4、0.8和1.6g/kg,容积均为10ml/kg。5min后再分别注射垂体后叶素(1U/kg)诱发急性心肌缺血,观察不同给药组大鼠心率(HR)变化,心律失常的发生情况,以及标Ⅱ导联心电图ST段抬高和T波幅度的改变。结果 5%酒精组心律失常发生率明显减少,心电图ST段抬高和T波高度显著降低,HR未受明显影响;10%酒精组HR减慢,但心电图ST段抬高和T波高度无明显变化;20%酒精组HR减慢,心电图ST段抬高、T波明显增高。结论 5%酒精组(0.4g/kg酒精)对垂体后叶素所致大鼠急性心肌缺血有保护作用,而20%酒精组(1.6g/kg酒精)的心肌缺血加重。

Effects of alcohol on acute myocardial ischemia induced by pituitrin in rats

Objective To observe the effects of alcohol intake at different levels on acute myocardial ischemia induced by pituitrin in rats.Methods Forty SD male rats were randomly divided into five groups,including model control group ( pituitrin,1U /kg),positive control group ( verapamil,1mg /kg),5% alcohol group (0.4g /kg),10% alcohol group (0.8g /kg) and 20% alcohol group (1.6g /kg).Myocardial ischemia model was made in rats by injecting pituitrin (1U /kg) through sublingual vein.The heart rate,incidence of arrhythmia,the changes of ST segment and T wave on electrocardiogram of rats were observed and compared.Results The incidence of arrhythmia,the degree of elevated ST segment and T wave amplitude induced by pituitrin were remitted obviously in the 5% alcohol group (0.4g /kg); The heart rate was slower and the change of ST segment and T wave were not affected in the 10% alcohol group (0.8g /kg).The heart rate was slower and the elevated ST segment and the T wave amplitude were augmented significantly in the 20% alcohol group (1.6g /kg).Conclusion A protective effect on acute myocardial ischemia induced by pituitrin in rats was shown in the 5% alcohol group (0.4g /kg) and an aggravation of acute myocardial ischemia induced by pituitrin was observed in the 20% alcohol group (1.6g /kg).