鸟嘌呤脱氨酶检测对肝脏疾病的诊断价值

采用比色法测定２００名不同疾病患者血清中鸟嘌呤脱氨酶（ＧＤ）活性，发现除肝脏疾病患者血清中ＧＤ活性高于正常外，其它疾病患者的ＧＤ活性均不升高。不同类型的肝脏疾病中，急性肝炎患者ＧＤ活性比慢性肝炎高，急慢性肝炎、肝内外胆道梗阻患者血清ＧＤ活性与丙氨酸氨基转移酶呈直线正相关；在慢性活动性肝炎、肝内外胆道梗阻、肝硬化时患者血清ＧＤ活性与总胆红素浓度呈直线正相关；抗ＨＣＶ阳性患者ＧＤ活性也显著升高。由此表明，血清ＧＤ检测是反映肝脏功能的一项特异、灵敏的指标，并有助于对急慢性肝炎、肝硬化的鉴别诊断及对丙型肝炎的诊断。

The Value of Determining Guanine Deaminase in Diagnosis of Hepatic Diseases

We determined the Guanine Deaminase(GD) activity of 200 patients with different diseases.It was found that GD activity of hepatic patients is higher than that of health adults,while the GD activity of other patients is in the normal range.There is a linear correlation between GD activity and ALT in patients with chronic hepatitis,billiary obstruction,and between GD activity and total bilirubin in patients with chronic active hepatitis,biliary obstruction and liver cirrhosis.Moreover,the GD activity of patients positive for anti HCV is significantly increased.So GD activity in serum is a specific and sensitive index to estimating hepatic functions and can be used in the diagnosis of acute and chronic hepatitis,cirrhosis of liver, and C virus hepatitis.