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| 氮酮和油酸增强黄芩苷经皮渗透作用的研究 | |
| 引用本文： | 杨巧丽,周雪琴,张志慧,王雷,王学艳,刘东志,姚康德.氮酮和油酸增强黄芩苷经皮渗透作用的研究[J].中草药,2006,37(7):1011-1013. |
| 作者姓名： | 杨巧丽 周雪琴 张志慧 王雷 王学艳 刘东志 姚康德 |
| 作者单位： | 1. 天津大学高分子材料研究所,天津,300072 2. 天津大学高分子材料研究所,天津,300072;天津大学化工学院,天津,300072 3. 天津市长征医院药剂科,天津,300021 4. 天津大学化工学院,天津,300072 |
| 基金项目： | 天津市自然科学基金资助项目(033610411) |
| 摘 要： | 目的研究氮酮、油酸及两者配伍对黄芩苷透皮吸收的促进作用。方法透皮吸收研究以改进型F ranz扩散池为模型,采用HPLC法测定黄芩苷透过量,以均匀设计法考察氮酮、油酸及两者配伍对黄芩苷透皮吸收的影响。结果氮酮体积分数为10%时,黄芩苷24 h累积透过量为466.11μg/cm2,油酸体积分数为14%时,24 h累积透过量为77.34μg/cm2,氮酮与油酸以10%∶0.5%配伍后24 h累积透过量为641.88μg/cm2,促渗性能为146.69。结论氮酮和油酸对黄芩苷的透皮吸收均有促进作用,两者配伍可产生协同促进作用,氮酮与油酸以10%∶0.5%配伍后促渗效果最好。 |
| 关 键 词： | 黄芩苷 氮酮 油酸 透皮吸收 |
| 文章编号： | 0253-2670（2006）07-1011-03 |
| 收稿时间： | 2005-09-30 |
| 修稿时间： | 2005-09-30 |
Enhancement of baicalin percutaneous penetration by azone and oleic acid |
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| YANG Qiao-li,ZHOU Xue-qin,ZHANG Zhi-hui,WANG Lei,WANG Xue-yan,LIU Dong-zhi and YAO Kang-de.Enhancement of baicalin percutaneous penetration by azone and oleic acid[J].Chinese Traditional and Herbal Drugs,2006,37(7):1011-1013. | |
| Authors: | YANG Qiao-li ZHOU Xue-qin ZHANG Zhi-hui WANG Lei WANG Xue-yan LIU Dong-zhi and YAO Kang-de |
| Institution: | 1. Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China; 2. School of Chemical Engineering, Tianjin University, Tianjin 300072, China; 3. Department of Pharmacy, Tianjin Changzheng Hospital, Tianjin 300021, China |
| Abstract: | Objective To study the effect of azone, oleic acid, and their combination on the transdermal obsorption of baicalin. Methods Improved Franz-cells and HPLC were used for the transdermal study. The effect of azone, oleic acid, and their combination on the transdermal absorption of baicalin was studied using uniform design. Results The 24h penetration amount of baicalin was obtained as 466. 11ug/cm2 and 77. 34ug/cm2 when the azone concentration was 10% or the oleic acid concentration was 14%, respectively. When using a combination of azone and oleic acid in the ratio of 10%:0.5%, the 24h penetration amount of baicalin was 641.88ug/cm2 and the enhancement ratio of penetration was 146.69. Conclusion Both azone and oleic acid could improve the skin penetration amount of baicalin. Combinated application of azone and oleic acid could further enhance baicalin transdermal delivery rate. The maximum penetration amount of baicalin is obtained by using a combination of azone and oleic acid in the ratio of 10%:0. 5% |
| Keywords: | baicalin azone oleic acid transdermal absorption |
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