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| Toll样受体4与动脉粥样硬化 | |
| 引用本文： | 王虹艳,曲鹏. Toll样受体4与动脉粥样硬化[J]. 心血管病学进展, 2005, 0(Z1) |
| 作者姓名： | 王虹艳 曲鹏 |
| 作者单位： | 大连医科大学附属第二医院心血管内科 辽宁大连116023(王虹艳)，大连医科大学附属第二医院心血管内科 辽宁大连116023(曲鹏) |
| 摘 要： | 动脉粥样硬化是一种慢性炎症疾病。Toll样受体家族(TLRs)识别抗原相关的分子模式(PAMPs)后激发先天性免疫反应。TLR4不仅识别外源性配体脂多糖(LPS),也识别动脉损伤过程中表达的内源性配体。越来越多的研究表明TLR4可能在动脉粥样硬化病变的发生和发展过程中发挥主要作用。现对近年有关TLR4在动脉粥样硬化中的作用的研究进展作一综述。此外,还将讨论对TLR4信号的可能干预措施。 |
| 关 键 词： | 动脉粥样硬化 炎症 先天免疫 Toll样受体4 |
Toll-like Receptor 4 and Atherosclerosis |
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| WANG Hong-yan,QU Peng. Toll-like Receptor 4 and Atherosclerosis[J]. Advances in Cardiovascular Diseases, 2005, 0(Z1) | |
| Authors: | WANG Hong-yan QU Peng |
| Abstract: | Atherosclerosis is a chronic inflammatory disease.The family of Toll-like receptors (TLRs) initiates an innate immune response after recognition of pathogen-associated molecular patterns (PAMPs).TLR4 recognizes not only exogenous ligands but also endogenous ligands that are expressed during arterial injury.Evidence is accumulating that TLR4 might play an important role in the initiation and progression of atherosclerotic disease.This review will summarize the latest progression in research on the role of TLR4 in atherosclerotic disease.In addition,the potential of intervention in TLR4 signalling to influence progression of atherosclerotic disease is discussed. |
| Keywords: | Atherosclerosis Inflammation Innate immunity:Toll-like receptor 4 |
| 本文献已被 CNKI 等数据库收录！ | |