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| pAdKDR-tk/GCV自杀基因系统联合γ射线放疗鼻咽癌的体内实验 | |
| 引用本文： | 邱前辉,孙伟,陈少华,黄晓明. pAdKDR-tk/GCV自杀基因系统联合γ射线放疗鼻咽癌的体内实验[J]. 临床耳鼻咽喉头颈外科杂志, 2010, 24(9) |
| 作者姓名： | 邱前辉 孙伟 陈少华 黄晓明 |
| 作者单位： | 1. 广东省人民医院耳鼻咽喉头颈外科,广东省医学科学院,广州,510080 2. 中山大学第二附属医院耳鼻咽喉头颈外科 |
| 基金项目： | 广东省自然科学博士科研启动项目(No:5300821) |
| 摘 要： | 目的:探讨pAdKDR-tk/GCV自杀基因系统联合γ射线放疗人鼻咽癌的杀伤效应。方法:分别以pAdKDR-tk/GCV、60Coγ射线放疗及两者联合治疗裸鼠人鼻咽癌移植瘤模型,比较疗效;利用肿瘤生长曲线及肿瘤抑瘤率评价该自杀基因系统联合放疗的疗效。结果:单纯基因治疗与放疗对鼻咽癌CNE-2细胞裸鼠皮下移植瘤生长的抑瘤率分别为58.43%和70.88%,而基因治疗与放疗联合应用的抑瘤率达到84.39%,与前两者比较,差异有统计学意义(P<0.01);第21天基因治疗与放疗联合治疗组肿瘤平均体积仅为对照组的13.5%,明显低于单纯基因治疗与放疗。结论:pAdKDR-tk/GCV自杀基因系统联合放疗的疗效较单一治疗方案有显著的提高,为进一步开展靶向肿瘤血管内皮自杀基因联合放疗研究奠定了良好的理论和临床基础。 |
| 关 键 词： | 单纯疱疹病毒-胸苷激酶 鼻咽肿瘤 自杀基因治疗 放射治疗 |
In vivo experimental study on nasopharyngeal carcinoma with combination of pAdKDR-tk/GCV suicide gene therapysystem and 60Co radiotherapy |
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| QIU Qianhui,SUN Wei,CHEN Shaohua,HUANG Xiaoming. In vivo experimental study on nasopharyngeal carcinoma with combination of pAdKDR-tk/GCV suicide gene therapysystem and 60Co radiotherapy[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2010, 24(9) | |
| Authors: | QIU Qianhui SUN Wei CHEN Shaohua HUANG Xiaoming |
| Affiliation: | 1Department of Otorhinolaryngology-Head and Neck Surgery/a>;Guangdong General Hospital/a>;Guangdong Academy of Medical Sciences/a>;Guangzhou/a>;510080/a>;China/a>;2Department of Otorhinolaryngology-Head and Neck Surgery/a>;the Second Affiliated Hospital of Sun Yat-sen University |
| Abstract: | Objective:To explore the killing effect of pAdKDR-tk/GCV suicide gene therapy system combined with 60Co radiotherapy on human nasopharyngeal carcinoma in vivo.Method:The pAdKDR-tk/GCV suicide gene therapy system and 60Co radiotherapy were used separately or in combination for human nasopharyngeal carcinoma in vivo to compare their effects. The tumor growth curve and inhibition rate of tumor to the cure effects of the combination of the pAdKDR-tk/GCV suicide gene therapy system and 60Co radiotherapy.Result:T... |
| Keywords: | herpes simplex virus thymidine kinase nasopharyngeal carcinoma suicide gene therapy radiotherapy |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |