| 宫颈癌癌变过程中Caspase-3、Fas/FasL的表达及其临床意义 |
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| 引用本文： | 徐虹,全培良,周云,王珍珍,蒋东霞. 宫颈癌癌变过程中Caspase-3、Fas/FasL的表达及其临床意义[J]. 河南医学研究, 2008, 17(1): 29-31 |
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| 作者姓名： | 徐虹 全培良 周云 王珍珍 蒋东霞 |
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| 作者单位： | 河南省肿瘤研究所,河南郑州,450003;河南省肿瘤医院肿瘤防治办公室,河南郑州,450003;河南省人民医院肿瘤科,河南,郑州,450003 |
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| 基金项目： | 河南省科研机构专项基金 |
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| 摘 要： | 目的:探讨宫颈癌癌变过程中Caspase-3、Fas/FasL蛋白表达的变化。方法:用免疫组织化学SP法检测42例宫颈癌、13例宫颈上皮内瘤样病变(cervical intraep ithelial neop lasia,C IN)和8例正常宫颈组织中Caspase-3、Fas/FasL蛋白的表达。结果:Caspase-3蛋白在正常宫颈组织、C IN及宫颈癌组织中的阳性表达率依次降低(P<0.05)。而Fas及FasL在C IN及宫颈癌组织中的表达与在正常组织中表达相比均有显著性差异(PFas<0.05;PFasL<0.05)。结论:宫颈癌组织能通过Caspase-3、Fas的表达及FasL高表达逃逸机体免疫监视以促使肿瘤发生发展及转移。
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| 关 键 词： | 宫颈内瘤样病变 宫颈癌 Fas蛋白 FasL蛋白 Caspase-3蛋白 |
| 文章编号： | 1004-437X(2008)01-0029-03 |
| 修稿时间： | 2008-02-19 |
The expression and clinical significance of Caspase-3 and Fas/FasL in cervical carcinogenesis |
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| XU Hong,QUAN Peiliang,ZHOU Yun,WANG Zhen-zhen,JIANG Dong-xia. The expression and clinical significance of Caspase-3 and Fas/FasL in cervical carcinogenesis[J]. Henan Medical Research, 2008, 17(1): 29-31 |
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| Authors: | XU Hong QUAN Peiliang ZHOU Yun WANG Zhen-zhen JIANG Dong-xia |
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| Affiliation: | XU Hong1); QUAN Peiliang2); ZHOU Yun3); WANG Zhen-zhen2); JIANG Dong-xia1)(1.Henan Tumor Institute; Zhengzhou 450003; China; 2.Office of Henan Provincial Cancer Control; Henan Tumor Hospital; 3.Department of Oncology; Henan Provincial People s Hospital; China); |
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| Abstract: | Objective: To investigate the expression of Caspase-3,Fas and FasL in cervical carcinogenesis.Methods: The expressions of Caspase-3,Fas and FasL,in 8 cases of normal cervix 13 cases of cervical intraepithelial neoplasia(CIN) and 36 cases of cervical carcinoma tissue were detected by immunohistochemistry.Results: The positive rates of Caspase-3 decreased from normal cervical,CIN to cervical carcinoma tissue(P<0.05);Fas and FasL expression were significantly different between each 2 groups(PFas<0.05;PFasL<0.05).Conclusion: Down-regulation of Caspase-3 and Fas expression but up-regulation of FasL expression may take part in carcinogenesis and development of cervical carcinoma,and this may be a mechanism by which the tumor cells evade the host immune surveillance. |
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| Keywords: | cervical neoplasis cervical carcinoma Fas protein Fas ligand protein Caspase-3 protein |
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