Analysis of IGG and IGG4 in HIV-1 seropositive patients and correlation with biological and genetic markers. |
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| Authors: | Aicha Abbas Alexandre Vasilescu Hervé Do Houria Hendel Mustapha Maachi Fran?ois-Xavier Goutalier Emmanuel G Regulier Jay Rappaport Fumihiko Matsuda Amu Therwath Pierre Aucouturier Jean-Fran?ois Zagury |
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| Affiliation: | 1. Immunochimie, Hôpital Tenon, Inserm E-0209 and Université Pierre et Marie Curie, Paris, France;2. Centre National de Génotypage, 2, rue Gaston Crémieux, 91057 Evry, France;3. Equipe Génomique, Bioinformatique et Pathologies du système immunitaire; Inserm EMI 0355, 15, rue de l''Ecole de Médecine, 75006 Paris, France;4. Laboratory of AIDS Pathogenesis and Therapeutics, Center for Cancer and Neurovirology, Temple University, Philadelphia, PA, USA;5. Chair de Bioinformatique, Conservatoire National des Arts et Métiers, 75003 Paris, France;1. Department of Computer Science and Numeric Analysis, University of Córdoba, Campus de Rabanales, 14071 Córdoba, Spain;2. Department of Computer Science and Automatic Control, UNED, Juan del Rosal 16, 28040 Madrid, Spain;1. Division of Epidemiology, Department of Family and Preventive Medicine, University of California, La Jolla, CA, USA;2. Division of Global Health, Department of Family and Preventive Medicine, University of California, La Jolla, CA, USA;3. Graduate School of Public Health, San Diego State University, San Diego, CA, USA;1. Department of Vascular Surgery, Royal Brisbane & Women''s Hospital, Herston, QLD, Australia;2. Discipline of Surgery, University of Queensland, Brisbane, QLD, Australia;3. School of Medicine, Griffith University, Gold Coast, QLD, Australia;4. Department of Pathology, Royal Brisbane & Women''s Hospital, Herston, QLD, Australia;5. Vascular Surgery, Greenslopes Private Hospital, Brisbane, QLD, Australia;1. Department of Ophthalmology, University of Michigan, Ann Arbor, Michigan;2. Unit of Ophthalmology, University of Siena, Policlinico Santa Maria alle Scotte, Siena, Italy;3. Unit of Ophthalmology, Santa Chiara Hospital, Pisa, Italy;1. Department of Pediatric Immunology and the Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands;2. Department of Pediatric Intensive Care/Pediatric Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands;3. Deparment of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands;1. Victorian Cytology Service, East Melbourne, VIC 3002, Australia |
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| Abstract: | ![]()
We have compared the levels of immunoglobulins G (IgG) and G4 (IgG4) in extreme seropositive patients from the GRIV cohort consisting of 168 patients with slow progression (SP) and 60 with rapid progression (RP) as well as in 173 healthy controls. IgG levels were significantly higher in SP patients than in RP patients (P = 0.008), both higher than in seronegative individuals. IgG4 levels were significantly lower in SP patients than in RP patients (P = 0.001), both lower than in seronegative individuals. We tried to correlate these levels with biological parameters (CD4(+) and CD8(+) cells, total lymphocytes, white blood cell counts, percentage of CD4(+) cells, and viral load) as well as with genetic markers from Th1/Th2 cytokines (IL2, IL4, IL6, IL10, IL13, and IFNgamma). IgG levels were correlated with the percentage of CD4(+) cells in SP while IgG4 levels were correlated with CD8(+) cell count in SP and with percentage of CD4(+) cells in RP patients. Among the parameters measured in SP patients at the time of inclusion in the study, the best predictor of progression towards AIDS was the viral load, the best predictor for stability was CD4(+) cell count, but overall, the best predictor for SP evolution (stability vs. progression) appeared to be the percentage of CD4(+) cells. Interestingly, correlations between the levels of IgG or IgG4 and the cytokine gene polymorphisms were found, notably in the IL10 gene. |
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