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Bradykinin antagonizes morphine-induced analgesia in rats
Authors:A Argiolas  M R Melis  G L Gessa
Affiliation:1. California Tobacco Prevention Program, California Department of Public Health, Sacramento, CA, USA;2. Center for Tobacco Control Research and Education, University of California San Francisco, CA, USA;3. Division of Oral Epidemiology and Dental Public Health, University of California San Francisco, San Francisco, CA, USA;1. Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland;2. Department of Pain Management and Research, Oslo University Hospital, Norway;3. Department of Anesthesiology, Oslo University Hospital, Norway;4. Faculty of Medicine, University of Oslo, Norway
Abstract:
The intraventricular injection of 5 micrograms of bradykinin or Met-Lys-bradykinin in rats antagonized the increase in nociception threshold induced by morphine (5 micrograms i.c.v. or 10 mg/kg i.p.) in the tail flick test. The effect of the two kinins was prevented by atropine (30 mg/kg i.p.). The results suggest that bradykinin counteracts opiate activity in the central nervous system by enhancing acetylcholine release.
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