阿托伐他汀对颈动脉粥样斑块及血脂的影响

目的 探讨阿托伐他汀对颈动脉粥样斑块的消退作用及降脂疗效.方法 应用彩色多普勒超声检测出颈动脉粥样斑块形成者126例,予以阿托伐他汀20mg/d,于治疗12周及24周时,检测治疗前、后颈动脉内膜中层厚度（IMT）及血脂变化.结果 阿托伐他汀治疗24周后,颈动脉IMT变薄（P〈0.05）,血总胆同醇（TC）、甘油三酯（TG）、低度密脂蛋白胆固醇（LDL-C）均明显下降（P〈0.05）,但在12周时,虽然TC、LDL-C明显下降,但IMT未见明显变化.结论 中小剂量阿托伐他汀长期服用可在降低血脂的同时有效消退颈动脉粥样斑块.

Effect of Atorvastatin Treatment on Carotid Plaque and Blood Lipid

Objective To investigate the effect of atorvastatin on carotid plaque and blood lipid in patients. Methods One hundred and twenty-six patients with carotid atheroma were treated with atorvastatin（20mg/d） for twelve weeks and twenty-four weeks.The carotid artery inner-intermediate thickness（IMT）were examined by the color Doppler and the level of lipids were observed before or after treatment. Results After twenty-four weeks of treatment,the IMT was obviously decreased and the levels of TC,TG,and LDL-C were decreased.But after twelve weeks of treatment,the IMT did not change obviously though the lipids were lowered. Conclusion Atorvastatin can prevent the progress of carotid atheroma and can obviously decrease blood lipid.