| 复合万古霉素海藻酸钠/壳聚糖缓释载体的体外释放研究 |
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| 引用本文： | 李瑞欣,马小军,王卫明,李诗荟,王为,赵德伟,郭林,于晓光,.复合万古霉素海藻酸钠/壳聚糖缓释载体的体外释放研究[J].中国医学工程,2010(2):5-9,14. |
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| 作者姓名： | 李瑞欣 马小军 王卫明 李诗荟 王为 赵德伟 郭林 于晓光 |
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| 作者单位： | 大连大学附属中山医院;中国科学院大连化学物理研究所; |
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| 基金项目： | 大连市科技局青年基金(2004B3SF157); 大连市科技局复合人才基金(2008J21JH001)资助; 辽宁省自然科学基金(20062135) |
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| 摘 要： | 目的探讨复合万古霉素海藻酸钠/壳聚糖(VCM/ACA)缓释系统中万古霉素缓释的动力学规律及影响因素。方法将万古霉素与海藻酸钠质量比分别为5:6和1:1的载体进行冷冻干燥处理和未冷冻干燥处理后制备成4组VCM/ACA载药载体。将载药载体放入pH7.2模拟体液PBS液中浸泡,通过测定浸泡液中万古霉素浓度,观察药物缓释的动力学规律和影响因素。结果 VCM/ACA载药载体的药物释放速度和释放量受载药量、调和比和冷冻干燥处理条件的影响。经冷冻干燥处理后调和比为1:1的载药载体可缓慢释药达250h以上。结论经过冷冻干燥处理万古霉素与海藻酸钠质量比(VCM:ALG)为1:1的载药载体体外能够稳定缓释万古霉素,可以满足临床实际需要。
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| 关 键 词： | 海藻酸钠/壳聚糖 万古霉素 药物缓释系统 体外实验 |
Drug Releasing Test In Vitro of Sodium Alginate/Chitosan Incorporated With Vancomycin as Drug Delivery System |
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| LI Rui-xin,MA Xiao-jun,WANG Wei-ming,et al.Drug Releasing Test In Vitro of Sodium Alginate/Chitosan Incorporated With Vancomycin as Drug Delivery System[J].China Medical Engineering,2010(2):5-9,14. |
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| Authors: | LI Rui-xin MA Xiao-jun WANG Wei-ming |
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| Institution: | LI Rui-xin1,MA Xiao-jun2,WANG Wei-ming1,et al(1 Affiliated Zhongshan Hospital Of Dalian University,Dalian Liaoning 116001,China,2 Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian Liaoning 116023,China) |
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| Abstract: | 【Objective】To investigate the delayed releasing profile and different factors effected in vitro in course of Sodium Alginate/Chitosan incorporated with Vancomycin（VCM/ACA） releasing.【Methods】The VCM /ACA implants were divided into 4 groups depending on ratio of power to mixing solution（VCM：ALG = 5：6 or 1：1）,with or without freezing and drying.Then each group of VCM /ACA implants were putting in bottle dipping and to observe the releasing characteristic.【Results】VCM/ACA implants can last more than 250.1 hours.The releasing characteristic dependented on drug amount,mixing solution volme and the management.【Conclusion】The VCM/ACA（1：1） implants under the management of freezing and drying has remarkable relseasing profile,can use to satisfy the need of clinical. |
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| Keywords: | Sodium alginate/chitosan Vancomycin Drug delivery system In vitro |
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