| 视网膜母细胞瘤中MMP-2、MMP-9和VEGF的检测及意义 |
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| 引用本文： | 周林,孙昊,徐岬,康建芳. 视网膜母细胞瘤中MMP-2、MMP-9和VEGF的检测及意义[J]. 现代医药卫生, 2010, 26(20): 3041-3043 |
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| 作者姓名： | 周林 孙昊 徐岬 康建芳 |
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| 作者单位： | 淮安市第二人民医院眼科,江苏,淮安,223002 |
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| 摘 要： | 目的:探讨基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)、基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)和血管内皮生长因子(vascular endothelial growth factor,VEGF)在视网膜母细胞瘤(retinoblastoma,RB)中的表达及其与RB分化程度和视神经浸润的关系.方法:采用免疫组化方法检测40例RB中MMP-2、MMP-9和VEGF的表达.结果:40例RB中MMP-2、MMP-9和VEGF的阳性表达率分别为52.5%、57.5%和72.5%.未分化型RB中MMP-2、MMP-9和VEGF的阳性表达均高于分化型(P＜0.05);有视神经浸润的RB中MMP-2、MMP-9和VEGF的阳性水平均高于无视神经浸润的RB(P＜0.05).RB中MMP-2、MMP-9和VEGF的表达呈正相关关系(P＜0.05).结论:RB中MMP-2、MMP-9和VEGF高表达与RB的浸润和转移相关,且MMP-2、MMP-9表达与VEGF表达存在相关性.联合检测MMP-2、MMP-9和VECF的表达可作为反映RB浸润、转移潜能的生物学指标,有助于筛选转移高危病例及评价患者预后.
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| 关 键 词： | 视网膜母细胞瘤 基质金属蛋白酶-2 基质金属蛋白酶-9 血管内皮生长因子 免疫组织化学 |
Detection of MMP-2, MMP-9 and VEGF in retinoblastoma and its significance |
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| ZHOU Lin,SUN Hao,XU Jia,et al.. Detection of MMP-2, MMP-9 and VEGF in retinoblastoma and its significance[J]. JOURNAL OF MODERN MEDICINE & HEALTH, 2010, 26(20): 3041-3043 |
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| Authors: | ZHOU Lin SUN Hao XU Jia et al. |
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| Affiliation: | ZHOU Lin,SUN Hao,XU Jia,et al. (Department of Ophthalmology, Huai’an Second People’s Hospital,Huai’an,Jiangsu223002,China) |
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| Abstract: | Objective:To study the expression of matrix metalloproteinase-2 (MMP-2),matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) in retinoblastoma (RB) and their relationship with the differentiation and optic nerve infiltration of RB and to investigate their role in the infiltration and metastasis and clinical significance.Methods:The immunohistochemical technique was used to detect the protein expression of MMP-2,MMP-9 and VEGF in 40 cases.Results:The positive rate of MMP-2, MMP-9 ... |
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| Keywords: | Retinoblastoma MMP-2 MMP-9 VEGF Immunohistochemistry |
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