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| 丹皮酚缓释微丸的制备工艺研究 | |
| 引用本文： | 程学仁,李智勇,王洛临,张建军,曾文雪. 丹皮酚缓释微丸的制备工艺研究[J]. 江西中医学院学报, 2012, 24(3): 43-46 |
| 作者姓名： | 程学仁 李智勇 王洛临 张建军 曾文雪 |
| 作者单位： | 广东省中医研究所 广州510095 |
| 基金项目： | 广东省中医药局建设中医药强省科研项目(项目编号:2010267) |
| 摘 要： | 目的:以Eudragit NE 30D为包衣材料,制备丹皮酚缓释微丸.方法:应用挤出滚圆机制备丹皮酚素丸和多功能制粒包衣机进行包衣制备缓释微丸,采用单因素法考察缓释微丸的制备工艺参数和包衣工艺参数.结果:体外释放度试验结果显示,所制丹皮酚缓释微丸具有明显的缓释特性.结论:制备的丹皮酚缓释微丸基本符合12 h缓释要求. |
| 关 键 词： | 丹皮酚 挤出滚圆 缓释微丸 |
Study on the Preparation of Paeonol Sustained Release Pellets |
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| CHENG Xue-ren , LI Zhi-yong , WANG Luo-lin , ZHANG Jian-jun , ZENG Wen-xue. Study on the Preparation of Paeonol Sustained Release Pellets[J]. Journal of Jiangxi College of Traditional Chinese Medicine, 2012, 24(3): 43-46 | |
| Authors: | CHENG Xue-ren LI Zhi-yong WANG Luo-lin ZHANG Jian-jun ZENG Wen-xue |
| Affiliation: | Guangdong province Institute of Traditional Chinese Medicine,Guangzhou510095 |
| Abstract: | Objective: To prepare Paeonol sustained-release pellets coated with Eudragit NE 30D.Methods: Paeonol pellets were pre pared by extrusion-spheronization machine,and coated preparation of sustained-release pellets prepared by multifunctional granulation coating machine,single factor was used to optimize the preparation parameters and coating parameters.Results: the results of in vitro re lease test shows that paeonol sustained-release pellets had a marked sustained-release property.Conclusion: The paeonol sustained re lease pellets prepared by this method can meet the requirements of 12h sustained release. |
| Keywords: | Paeonol extrusion-spheronization technology sustained-release pellets |
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