尿多酸肽对晚期非小细胞肺癌化疗患者免疫功能的影响

[目的]探讨尿多酸肽对晚期非小细胞肺癌患者的细胞免疫功能的影响.[方法]45例晚期非小细胞肺癌患者.单纯化疗组26例,采用NP(NVB DDP)方案化疗.尿多酸肽联合化疗组19例,NP方案化疗联合应用尿多酸肽静脉滴注4～8周.两组均于化疗前及化疗2周期后,采用流式细胞仪检测T细胞亚群.[结果]单纯化疗组化疗前、后CD3 、CD 4、CD 8以及CD 4/CD 8差异显著(P＜0.05),化疗后免疫功能明显下降.尿多酸肽联合化疗组治疗前、后CD 3、CD 4/CD8 无显著性差异(P＞0.05),免疫功能无明显变化.两组化疗后CD 3、CD 4以及CD 4/CD8 比较差异显著(P＜0.01),联合尿多酸肽组化疗后免疫功能明显高于单纯化疗组.[结论]晚期非小细胞肺癌患者普遍存在免疫功能紊乱和低下,化疗使细胞免疫功能进一步降低,尿多酸肽能促进化疗患者细胞免疫功能的恢复.

The Effects of Urineside on Immunity of Patients with Advanced Non-small Cell Lung Cancer

To evaluate the effect of Urineside on immunity of patients with advanced non-small cell lung cancer.Forty-five patients with advanced non-small cell lung cancer were enrolled.Twenty-six patients received chemotherapy with NVB DDP and 19 patients received the same regiment combined with Urineside for 4 to 8 weeks.The changes of T-lymphocyte subgroups were measured with the flow cytometry method before and after 2 cycles chemotherapy in the patients.The ratio of CD4 /CD8 in patients with advanced non-small cell lung cancer before chemotherapy was significantly lower than that in control group(P<0.05). In the chemotherapy group, the count of CD3 ?CD4 cells and the ratio of CD4 /CD8 lowered after chemotherapy(P<0.05), that indicates the immunity decreased after chemotherapy.In the Urineside group,no significant changes of CD3 cells and the ratio of CD4 /CD8 pre- and post-treatment were observed (P>0.05), the immunity had no significant changes.After chemotherapy,CD3 and CD4 cells and the ratio of CD4 /CD8 of the two groups had significant difference,the immunity in Urineside group was obviously higher than that in chemotherapy group.[Conclusion]The immunity is suppressed in the patients with advanced non-small cell lung cancer.The immunity lowers after chemotherapy.Urineside can improve the cell immunity in patients undergoing chemotherapy.