不同妊娠期孕妇甲状腺功能指标参考范围建立

目的:探讨不同妊娠期甲状腺功能指标参考范围,为本地区妊娠期甲状腺疾病提供可靠的诊断依据。方法:选择首次来本院进行甲状腺功能检测的不同妊娠期妇女为研究对象,分为妊娠早期(孕1~12周)、妊娠中期(孕13~27周)、妊娠晚期(孕28~40周),同期非妊娠妇女为对照组,各组220例,行促甲状腺激素(TSH)和游离甲状腺素(FT4)筛查。结果:检测中位数TSH分别为妊娠早期0.02~4.27mIU/L,妊娠中期0.08~5.07mIU/L,妊娠晚期期0.48~5.08mIU/L;FT4分别为妊娠早期12.08~24.80pmol/L,妊娠中期9.76~17.82pmol/L,妊娠晚期9.27~16.10pmol/L。与其他妊娠期及对照组比较,妊娠早期TSH水平最低,FT4最高(P<0.05)。结论:建立本地区不同妊娠期甲状腺功能指标参考值,有利于妊娠期甲状腺疾病的筛查及诊治。

The establishment of reference range of thyroid function indexes of pregnant women during different gestational weeks

Objective:To explore the reference range of thyroid function indexes of pregnant women during different gestational weeks,and to provide reliable evidence for diagnosing thyroid diseaseof women during pregnancy.Methods:The pregnant women during different gestational weeks who firstly for thyroid function testing were selected as the study objects,which included 220 women during the first trimester pregnancy(in 1-12 gestational weeks)in group A,220 women during the second trimester pregnancy(in 13-27 gestational weeks)in group B,220 women during the third trimester pregnancy(in 28-40 gestational weeks)in group C,and 220 women without pregnancy in group D.The levels of thyrotrophin(TSH)and free thyroxine(FT4)of all women were detected.Results:The median level of TSH of women in group A,B,and C were 0.02-4.27mIU/L,0.08-5.07mIU/L,and 0.48-5.08mIU/L,respectively.And the median level of FT4 of women in group A,B,and C were 12.08-24.80pmol/,9.76-17.82pmol/L,and 9.27-16.10pmol/L,respectively.Of women in group A,the TSH level was the lowest,but FT4 level was the highest(P<0.05).Conclusion:The establishment of range of thyroid function indexes of pregnant women during different gestational weeks is beneficial to the screening and diagnosis of thyroid diseases of pregnant women.