MHC2TA and FCRL3 genes are not associated with rheumatoid arthritis in Mexican patients |
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| Authors: | J. F. Mendoza Rincón A. K. Rodríguez Elias J. M. Fragoso G. Vargas Alarcón K. Maldonado Murillo M. L. Rivas Jiménez R. E. Barbosa Cobos S. Jimenez Morales G. Lugo Zamudio C. Tovilla Zárate J. Ramírez Bello |
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| Affiliation: | 1.Laboratorio de Oncología Molecular, Unidad de Diferenciación Celular y Cáncer, FES-Zaragoza,UNAM,Mexico City,Mexico;2.Programa de Maestría en Biología Experimental,UAM-I,México City,Mexico;3.Departamento de Biología Molecular,Instituto Nacional de Cardiología Ignacio Chávez,Mexico City,Mexico;4.Licenciatura en Biología, Facultad de Estudios Superiores, Zaragoza,UNAM,Mexico City,Mexico;5.Servicio de Reumatología,Hospital Lic. Adolfo López Mateos,Mexico City,Mexico;6.Servicio de Reumatología,Hospital Juárez de México,Mexico City,Mexico;7.Dirección de Investigación,Instituto Nacional de Medicina Genómica,Mexico City,Mexico;8.División de Medicina,Hospital Juárez de México,Mexico City,Mexico;9.División Académica Multidisciplinaria de Comalcalco,Universidad Juárez Autónoma de Tabasco,Comalcalco,Mexico;10.Laboratorio de Medicina Genómica, Unidad de Investigación,Hospital Juárez de México,Mexico City,Mexico |
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| Abstract: | Rheumatoid arthritis (RA) is a multifactorial disease. A combination of genetic and environmental risk factors contributes to its etiology. Several genes have been reported to be associated with susceptibility to the development of RA. The MHC2TA and FCRL3 genes have been associated previously with RA in Swedish and Japanese populations, respectively. In two recent reports, we show an association between FCRL3 and juvenile rheumatoid arthritis (JRA), and MHC2TA and acute coronary syndrome (ACS) in Mexican population. We assessed the association between three single nucleotide polymorphisms (SNPs) of the MHC2TA (?168G/A; rs3087456, and +16G/C; rs4774) and FCRL3 (?169T/C; rs7528684) genes and rheumatoid arthritis in Mexican population through a genotyping method using allelic discrimination assays with TaqMan probes. Our case–control study included 249 patients with RA and 314 controls. We found no evidence of an association between the MHC2TA ?168G/A and +1614G/C or FCRL3 ?169T/C polymorphisms and RA in this Mexican population. In this cohort of Mexican patients with RA, we observed no association between the MHC2TA or FCRL3 genes and this autoimmune disease. |
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