Pharmacokinetics and pharmacodynamics of gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a granulocyte-rich exudate |
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| Authors: | Trampuz Andrej Laifer Gerd Wenk Markus Rajacic Zarko Zimmerli Werner |
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| Affiliation: | Division of Infectious Diseases, Departments of Internal Medicine and Research, University Hospitals, Basel, Switzerland. |
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| Abstract: | ![]()
The pharmacokinetics of gatifloxacin were assessed in serum and in skin blister fluid (SBF), as was the pharmacodynamic activity in SBF. Five hours after a single dose of gatifloxacin, SBF killed 2.5 logs of Streptococcus pneumoniae and 1.5 log of Staphylococcus aureus during a 2-h incubation ex vivo. |
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