丁胺卡那霉素对新生儿耳毒性的研究

目的 探讨丁胺卡那霉素对新生儿的耳毒性。方法 选取疑有感染性疾病而需用抗生素的足月新生儿34例,根据丁胺卡那霉素用药剂量及方法分为4组,另设6例作对照。结果 全部对象听觉脑干诱发反应（ABR）波及波间潜伏时均值正常,每天1次用药组21例中有3例异常,而每天2次用药组13例中有5例异常,其判别有极显著意义。随访4例异常者,其中3例恢复正常。结论 34例中有8例ABR异常,每天2次用药者的异常率是每天1次用药的3倍。提示使用丁胺卡那霉素治疗＜7天,每天1次用药,发生听力损害的可能小,即使发生,也是可逆的。

Study of Ototoxicity in Newborn With Amikacin.

Objective To evaluate the changes of ototoxicity in newborn children given Amikacin therapy. Methods It was divided into four groups for study that the 34 neonates suspected infection required Amikacin therapy,and 6 for control group. Results All wave latency average values of the subjects were normal.The incidenceof auditory brainstem response(ABR) abnormality of those taken Amikacin twice daily was much higher than those with once daily,it was significant difference( P <0.01).Auditory toxicity was detected in 3 of the twenty one Amikacin treated patients once daily and in 5 of the thirteen patients twice daily.4 case werefollowed up after discharge. Conclusions 8 of 34 cases had ABR abnormality.Ototoxicity were positively related to the usage of Amikacin.The incidence of ABR abnormality of those with twice daily is 3 times more than those with once daily.The results indicate that the risk is small,when the therapeutic couse of Amikacinwas <7 days, that clinical significant hearing impairment will be development, even ABR abnormality presented,it will recover soon.