Ammonia: a possible promotor in Helicobacter pylori-related gastric carcinogenesis. |
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| Authors: | M Tsujii S Kawano S Tsuji K Nagano T Ito N Hayashi H Fusamoto T Kamada K Tamura |
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| Affiliation: | Department of Medicine, Osaka University Medical School, Japan. |
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| Abstract: | Helicobacter pylori (HP) has been shown to possibly be a pathogen of gastric carcinoma. HP has urease activity and produces ammonia in the stomach. In this study, the role of ammonia on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in rats. After 24 weeks pretreatment with MNNG (83 mg/l), 0.01% ammonia or tap water as a drinking water was administered for 24 weeks. The ammonia-treated rats showed a significantly higher incidence of gastric cancer (percent of animals with tumors and number of tumors per rat). Ammonia would thus appear to have an important role in HP-related human gastric carcinogenesis. |
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