不同年龄HBsAg阳性患者肝功能和血脂变化及临床意义

目的：探讨不同年龄HBsAg阳性患者肝功能和血脂变化的临床意义。方法：回顾性调查1121例HBsAg阳性患者及1121例年龄、性别相匹配的HBsAg阴性健康对照组肝功能和血脂水平。结果：HBsAg阳性患者ALT、AST、TBIL、DBIL分别为（48±162）U／L、（40±136）U／L、（14．8±15．5）μmol／L、（5．9±13．7）μmol/L，明显比HBsAg阴性对照组高（P〈0．001）；而HBsAg阳性患者TC、TG却明显比HBsAg阴性对照组低（P〈0．001），TC分别为（4．55±1．07）、（5．13±1．32）mmol]L，TG分别为（1．16±1．14）、（1．52±1．36）mmol／L。HBsAg阳性患者ALT、AST均以31-40岁组最高，41—50岁组次高；TP、ALB均以≥61岁组最低；TC以41～50岁组最低．≥61岁组次低，31～40岁组稍低。结论：HBsAg阳性患者存在不同程度的肝脏损害和脂代谢障碍．31～50岁青壮年HBsAg阳性患者肝细胞损伤较重，〉61岁老年HBsAg阳性患者肝细胞合成功能降低。

Clinical significance of liver function and changes of serum lipoids in HBsAg positive patients in different ages

Objective： To study the clinical significance of liver function and changes of serum lipoids in HBsAg positive patients in different ages. Methods： The levels of parameters of liver function and serum lipoids were retrospectively reviewed in the group of 1 121 HBsAg positive patients and compared with controlled group of 1 121 HBsAg negative healthy subjects. Results： The study revealed that HBsAg positive patients had significantly higher levels of ALT, AST, TBIL and DBIL, compared to that of the control group （P〈0.001）, the concentrations of ALT, AST, TBIL and DBIL in HBsAg positive patients were （48±162） U/L, （41±136） U/L, （14.8±15.5）μmol/L and （5.9±13.7） μmol/L, respectively. However, the concentrations of TC and TG in HBsAg positive patients were obviously lower than that of control group （4.55±1.07） vs （5.13±1.32） mmol/L, （1.16±1.14） vs （1.52±1.36） mmol/L, respectively, P〈0.001. The levels of ALT as well as AST of 31 to 40 years old patients of HBsAg positive group were the highest, while that of 41 to 50 years old patients were secondary higher. The concentrations of TP and ALB of the patients of more than 61 years old HBsAg positive group were the lowest. The level of TC of 41 to 50 years old patients of HBsAg positive group was the lowest, while level of TC of more than 61 years old patients was secondary lower, and level of TC of 31-40 years old patients was tertiary lower. Conclusion： HBsAg positive patients have certainly hepatic lesion and lipoidosis. The hepatocellular injury of 31-50 years old patients of HBsAg positive group is serious. The function of hepatocellular synthesis of more than 61 years old patients of HBsAg positive group is lower.