| 低压低氧对大鼠海马神经元NMDA受体发育影响的研究 |
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| 引用本文： | 黄辉,阮怀珍,吴喜贵,范晓棠,张金海.低压低氧对大鼠海马神经元NMDA受体发育影响的研究[J].第三军医大学学报,2001,23(6):655-657. |
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| 作者姓名： | 黄辉 阮怀珍 吴喜贵 范晓棠 张金海 |
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| 作者单位： | 第三军医大学基础医学部神经生物学教研室, |
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| 基金项目： | 全军“九五”医药卫生科研基金资助项目 (98M0 89) |
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| 摘 要： | 目的 观察低压低氧环境对海马发育过程中学习记忆、NMDA受体1和生长抑素mRNA表达的影响。方法 采用模拟高原低氧模型，运用原位杂交及行为学技术。结果 低压低氧环境使NMDA受体1和生长抑素mRNA的表达发生改变，大鼠的主动回避反应和空间学习记忆功能下降。结论 低压低氧环境可以通过改变NMDA受体和生长抑素的表达而对学习记忆产生一定的影响。
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| 关 键 词： | 高原低氧 学习记忆 NMDA受体 生长抑素 大鼠 海马神经 |
| 文章编号： | 1000-5404(2001)06-0655-03 |
| 修稿时间： | 2001年2月1日 |
Effect of hypobaric hypoxia on NMDA receptor of hippocampus neurons in developing rats |
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| HUANG Hui,RUAN Huai zhen,WU Xi gui,FAN Xiao tang,ZHANG Jin hai.Effect of hypobaric hypoxia on NMDA receptor of hippocampus neurons in developing rats[J].Acta Academiae Medicinae Militaris Tertiae,2001,23(6):655-657. |
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| Authors: | HUANG Hui RUAN Huai zhen WU Xi gui FAN Xiao tang ZHANG Jin hai |
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| Abstract: | Objective To observe the effect of hypobaric hypoxia on learning and memory abilities, NMDA receptor 1 and somatostatin mRNA expressions during the development at stage of hippocampus. Methods In situ hybridization hitochemical method and behaviour training were used in the rat model of hypobaric hypoxia. Results The active avoidance reaction and spatial memory ability were impaired in rats under hypobaric hypoxia. NMDA mRNA and somatostatin mRNA were overexpressed in the first 3 d and then down regulated in the next few days under hypobaric hypoxia. Conclusion NMDA receptor and somatostatin is involved in the learning and memory changes in rats under hypobaric hypoxia. |
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| Keywords: | hypobaric hypoxia learning and memory NMDA receptor somatostatin |
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