| 白花蛇舌草核苷体外抗肿瘤作用实验研究 |
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| 引用本文： | 张鹏,赵启韬,杨培民,代龙,魏永利,高鹏,曹广尚.白花蛇舌草核苷体外抗肿瘤作用实验研究[J].时珍国医国药,2012,23(8):1901-1902. |
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| 作者姓名： | 张鹏 赵启韬 杨培民 代龙 魏永利 高鹏 曹广尚 |
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| 作者单位： | 1. 山东中医药大学,山东济南,250355
2. 山东中医药大学附属医院,山东济南,250011 |
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| 基金项目： | 山东省自然科学基金(No.ZR2011HL043) |
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| 摘 要： | 目的 探讨白花蛇舌草中核苷的体外抗肿瘤作用.方法 采用24孔板培养法和MTT法观察白花蛇舌草核苷对人红白血病细胞株K562、人非小细胞肺癌细胞株A549的抑制作用.结果 显微镜下观察24孔板,白花蛇舌草核苷呈现明显的抗肿瘤作用.体外抑瘤实验表明,白花蛇舌草核苷对两种细胞株起效的最低药物浓度分别为100 μg/ml和50μg/ml,半数致死量IC50分别是248.1 μg/ml和147.7 μg/ml.结论 白花蛇舌草核苷具有抗肿瘤活性.
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| 关 键 词： | 白花蛇舌草 核苷 MTT法 抗肿瘤 |
Experimental Research of Anti-tumor Effect of Nucleoside in Hedyotis Diffusa |
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| ZHANG Peng
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ZHAO Qi-tao
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YANG Pei-min
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DAI Long
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WEI Yong-li
,
GAO Peng
,
CAO Guang-shang.Experimental Research of Anti-tumor Effect of Nucleoside in Hedyotis Diffusa[J].Lishizhen Medicine and Materia Medica Research,2012,23(8):1901-1902. |
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| Authors: | ZHANG Peng ZHAO Qi-tao YANG Pei-min DAI Long WEI Yong-li GAO Peng CAO Guang-shang |
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| Institution: | 1.Shandong University of TCM,Jinan 250355,China;2.Hospital Affiliated to Shandong University of TCM,Jinan 250011,China) |
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| Abstract: | Objective To research antineoplastic activity of the nucleoside in Hedyotis diffusa.Methods The inhibitory effects of Nucleoside in Hedyotis diffusa on proliferation lenkemia cellline k562 and human lung cancer cell line A549 were observed with MTT method.Results Nucleoside in Hedyotis diffusa showed strong anti-tumor effect.The lowest sensitive drug concentration was 100μg/ml and 50μg/ml,respectively.IC50 was 245.3μg/ml and 129.1μg/ml,respectively.Conclusion The nucleoside in Hedyotis diffusa has strong anti-tumor effect in vitro. |
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| Keywords: | Hedyotis diffusa Nucleoside MTT method Anti-tumor effect |
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