| Notch信号通路在眼科疾病发生发展中的调控作用 |
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| 引用本文： | 周梦贤,李土玲,殷学伟,毕宏生,郭大东.Notch信号通路在眼科疾病发生发展中的调控作用[J].国际眼科杂志,2021,21(10):1707-1710. |
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| 作者姓名： | 周梦贤 李土玲 殷学伟 毕宏生 郭大东 |
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| 作者单位： | 中国山东省济南市,山东中医药大学,中国山东省济南市,山东中医药大学,中国山东省济南市,山东中医药大学,中国山东省济南市,山东省中西医结合眼病防治重点实验室 山东省高校中西医结合眼病防治技术(强化)重点实验室 山东中医药大学眼科研究所,中国山东省济南市,山东省中西医结合眼病防治重点实验室 山东省高校中西医结合眼病防治技术(强化)重点实验室 山东中医药大学眼科研究所 |
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| 基金项目： | 国家自然科学基金(No.81873163); 国家重点研发计划(No.2019YFC1710200) |
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| 摘 要： | Notch信号通路是一种进化上高度保守的信号通路，广泛存在于各类组织细胞中，在胚胎发育、细胞增殖、分化和凋亡，维持多细胞生物稳态、血管生成以及多种癌症的发生发展过程中起重要作用。近年来研究发现Notch信号通路在白内障、葡萄膜炎、视网膜病变等多种眼科疾病中会表现为异常活化，调控着相关眼科疾病的发生和发展过程。本文就Notch信号通路在眼科疾病发生发展过程中的调控作用做简要综述。
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| 关 键 词： | Notch信号通路 白内障 葡萄膜炎 年龄相关性黄斑变性 调控作用 |
| 收稿时间： | 2020/12/2 0:00:00 |
| 修稿时间： | 2021/8/31 0:00:00 |
Research advances in the regulatory role of Notch signaling pathway in the occurrence and development of eye diseases |
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| Meng-Xian Zhou,Tu-Ling Li,Xue-Wei Yin,Hong-Sheng Bi and Da-Dong Guo.Research advances in the regulatory role of Notch signaling pathway in the occurrence and development of eye diseases[J].International Journal of Ophthalmology,2021,21(10):1707-1710. |
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| Authors: | Meng-Xian Zhou Tu-Ling Li Xue-Wei Yin Hong-Sheng Bi and Da-Dong Guo |
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| Institution: | Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China,Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China,Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China,Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases;Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases in Universities of Shandong;Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China and Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases;Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases in Universities of Shandong;Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China |
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| Abstract: | The Notch signaling pathway is an evolutionarily highly conserved signaling pathway that exists in a wide variety of tissue cells and plays an important role in embryonic development, cell proliferation, differentiation and apoptosis, as well as in the maintenance of multicellular biosynthesis, angiogenesis, and the development of various cancers. In recent years, it has been found that the Notch signaling pathway is abnormally activated in cataract, uveitis and other ophthalmic diseases, regulating the process of ocular disease development. This article provides a brief review of the regulatory role of the Notch signaling pathway in the development of ophthalmic diseases. |
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| Keywords: | Notch signaling pathway cataract uveitis age-related macular degeneration regulatory role |
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