卵巢恶性肿瘤患者血浆纤维蛋白原及血小板四项参数检测的临床意义

[目的 ]探讨血浆纤维蛋白原水平及血小板计数与卵巢恶性肿瘤的关系。 [方法 ]选择经手术病理或临床证实的卵巢恶性肿瘤患者 4 6例 ,卵巢良性肿瘤患者 4 5例 ,所有患者治疗前抽血 ,检测血浆纤维蛋白原 (fibrinogen ,FIB)及血小板四项参数 ,包括血小板计数 (PLT)、血小板分布宽度(PDW )、平均血小板体积 (MPV)和血小板压积 (PCT) ,进行回顾性分析。[结果 ]卵巢恶性肿瘤患者平均血浆FIB含量为 (5 84 .1± 190 .4 )mg/dL(x±s) ,其平均血小板计数为 (2 6 8.0± 10 6 .4 )×10 4 /fL(x±s) ,与卵巢良性肿瘤患者比较差异显著 (P <0 .0 1)。卵巢恶性肿瘤患者的血浆FIB水平与肿瘤的病理类型和临床分期无关 ;卵巢恶性肿瘤患者的血小板计数与肿瘤的病理类型和临床分期有关。[结论 ]血小板计数及血浆纤维蛋白原水平测定 ,对筛查和早期发现卵巢恶性肿瘤有一定意义 ,可作为诊断卵巢恶性肿瘤的一种补充指标 ,并对卵巢恶性肿瘤患者病情评估与预后判断有重要意义。

Clinical significance of blood platelet count and serum fibrinogen in patients with ovarian carcinoma

[Objective] To explore the clinical significance of blood platelet count and serum fibrinogen content in diagnosed ovarian carcinoma cases. [Methods] Forty-six cases of ovarian carcinoma were demonstrated by pathologic or clinical diagnosis. Serum fibrinogen (FIB) content was measured by using automated coagulation analyzer SYSMEX CA-6000, and platelet count (PLT) was measured automatically by using blood cell counter Coulter JT. [Results] The average levels of serum fibrinogen and blood platelet count in the patients with ovarian carcinoma were(584.1±190.4)mg/dL(x±s) and (268.0±106.4)×10 4/fL (x±s) respectively. Significant difference was observed in detection of PLT and serum FIB levels between ovarian carcinoma group and benign ovarian tumors group (P<0.01). [Conclusion] The level of PLT and serum FIB could be used as a complementary parameter in the diagnosis of ovarian carcinoma, and they have the important significance for the selecting and assessing the state of ovarian carcinoma.