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Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants
Affiliation:1. Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan;2. Tokyo Shinagawa Hospital, Tokyo, 140-8522, Japan;3. Department of Life Science and Medical Bioscience, Waseda University, Tokyo, 162-8480, Japan;4. Department of Virology I, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan;5. Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, 208-0011, Japan;6. Department of Pathology, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan;7. Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan;8. AIDS Research Center, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan;9. Yokohama Municipal Citizen’s Hospital, Kanagawa, 221-0855, Japan;10. Tokyo Medical University, Tokyo, 160-8402, Japan;11. Kawakita General Hospital, Tokyo, 166-0001, Japan;12. Center for Emergency Preparedness and Response, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan;13. National Institute of Infectious Diseases, Tokyo, 162-8640, Japan
Abstract:
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  • Keywords:SARS-CoV-2  SARS-CoV-2 variants of concern  neutralizing antibody  affinity maturation
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