前列腺素E1及硝酸甘油在离体肺保护中应用的实验研究

应用兔离体肺再灌注模型研究前列腺素Ｅ１（ＰＧＥ１）及硝酸甘油（ＮＴＧ）在离体肺保护中的作用。１８只兔随机平均分为两组，对照组以ＬＰＤ液进行肺灌洗及保存，用药组以ＰＧＥ１１００μｇＬ－１及ＮＴＧ１０ｍｇＬ－１加入ＬＰＤ液中进行肺灌洗及保存。每组再分为三小组（各含６个肺）分别保存２、４、８小时后进行再灌注，测定再灌注后肺血管阻力（ＰＶＲ），肺通气阻力（ＬＲ），肺含水量（ＬＷ）及动脉血氧分压（ＰａＯ２）以了解肺保护效果。结果示：用药组再灌注后ＰＶＲ明显低于对照组（Ｐ＜０．０５）。ＬＲ、ＬＷ及ＰａＯ２两组无差别。说明ＰＧＥ１及ＮＴＧ在保护肺血管内皮细胞及降低再灌注后肺血管阻力方面明显优于对照组。ＰＧＥ１及ＮＴＧ作用机理可能是通过肺动脉扩张改善肺早期灌洗及抵制中性粒细胞，血小板在肺内聚集而减轻肺再灌注损伤

Effect of prostaglandin E1 and nithoglycerin on lung preservation

Using isolated-lung reperfusion model,the effects of prostaglandin E1(PGEI)andnitroglycerin(NTG)on lung preservation were studied in 18 rabbits which were randomly dividedinto two groups(9 rabbits in each group).In the control group,the lungs were flushed and pre-group was then divided into three subgroups.Reperfusion was performed in each subgroup at 2 h,4 h and 8h.respectively.Pulmonary vascular resistance(PVR),lung resistance(LR),lung wa-ter(LW)and blood gas after reperfusion were determined,It was found that:1)PVR was muchlower in the treated group than in the control group(P＜0.05);2)No difference was found inLR,LW and P02 between the two groups.It was concluded that PGE1 and NTG can improved thelung preservation by protecting the pulmonary vascular endothelial cells and decreasing the PVRafter reperfusion.