参麦注射液对老年晚期乳腺癌患者心力衰竭期心功能及血清N末端B型利钠肽原、超敏心肌肌钙蛋白T的影响

目的:探讨参麦注射液对老年晚期乳腺癌患者心力衰竭期心功能及血清N末端B型利钠肽原(NT-proBNP)、超敏心肌肌钙蛋白T(hs-cTnT)的影响.方法:选取2018年6月至2019年12月上海市宝山区中西医结合医院收治的心力衰竭期老年乳腺癌患者94例作为研究对象,采用随机数字法分为对照组(n=47)和观察组(n=47...

Effect of Shenmai Injection on Heart Function,Serum N-Terminal B-Type Natriuretic Peptide and Hypersensitive Cardiac Troponin T in Elderly Patients with Advanced Breast Cancer at Heart Failure Stage

OBJECTIVE:To explore the effects of Shenmai injection on heart function,serum N-terminal B-type natriuretic peptide(NT-proBNP)and hypersensitive cardiac troponin T(hs-cTnT)in elderly patients with advanced breast cancer at heart failure stage.METHODS:Totally 94 patients with advanced breast cancer at heart failure stage admitted into Shanghai Baoshan Integrated Hospital of Traditional Chinese and Western Medicine from Jun.2018 to Dec.2019 were extracted to be divided into the control group(n=47)and the observation group(n=47)via the random number table.The control group received conventional symptomatic treatment,while the observation group was treated with Shenmai injection on the basis of the control group.Clinical efficacy,changed of cardiac function such as left ventricular ejection fraction(LVEF),cardiac output(CO),early diastolic maximum flow velocity/late diastolic maximum flow velocity(E/A),serum creatine kinase isoenzyme(CK-MB),creatine kinase(CK),NT-proBNP and hs-cTnT levels before and after treatment were observed in two groups.RESULTS:After treatment,the total effective rate of the observation group was 87.23%(41/47),significantly higher than 65.96%(31/47)of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of LVEF,ratio of CO and E/A in two groups increased significantly,and the observation group was significantly better than the control group,with statistically significant difference(P<0.05).After treatment,the levels of CK-MB,CK,NT-proBNP and hs-cTnT in two groups decreased significantly,and the improvement in the observation group was better than that in the control group,with statistically significant difference(P<0.05).CONCLUSIONS:Shenmai injection can significantly improve the cardiac function of elderly patients with advanced breast cancer by increasing the myocardial contractility and the anti-lipid peroxidation,reducing the risk of myocardial injury and heart failure and improving the clinical efficiency.