百令胶囊联合多索茶碱治疗老年慢性阻塞性肺疾病稳定期患者的临床研究

目的:探讨百令胶囊联合多索茶碱治疗老年慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期患者的临床疗效。方法:选择2018—2019年都江堰市人民医院收治的老年COPD稳定期患者200例,采用随机数字表法分为对照组(100例)和观察组(100例)。对照组患者采用多索茶碱治疗,观察组患者采用百令胶囊联合多索茶碱治疗。两组患者均连续给予治疗8周。治疗后进行临床疗效评定;比较两组患者治疗前后的中医证候积分,多因素分级系统(body mass index,obstruction,dyspnea,exercise,BODE)指数和圣乔治呼吸问卷(St.George’s respiratory questionaire,SGOR)评分,第1 s用力呼气容积(FEV1)、用力肺活量(FVC),血清单核细胞趋化蛋白-1(MCP-1)、8-羟基脱氧鸟苷酸(8-OHdG)水平;观察两组患者治疗过程中不良反应的发生情况。结果:观察组患者的临床总有效率为95.00%(95/100),明显较对照组的80.00%(80/100)高,差异有统计学意义(χ²=10.286,P=0.001)。两组患者治疗后的中医证候积分、BODE指数及SGOR评分明显低于治疗前;同时,观察组治疗后的中医证候积分、BODE指数及SGOR评分明显低于对照组,上述差异均有统计学意义(P<0.05)。观察组及对照组患者治疗后的FEV1、FVC水平较治疗前明显升高,且观察组患者的FEV1、FVC水平明显高于对照组,上述差异均有统计学意义(P<0.05)。观察组及对照组患者治疗后的血清MCP-1、8-OHd G水平明显低于治疗前,且观察组患者明显低于对照组,上述差异均有统计学意义(P<0.05)。观察组、对照组患者的不良反应发生率分别为5.00%(5/100)、6.00%(6/100),差异无统计学意义(P>0.05)。结论:百令胶囊联合多索茶碱治疗老年COPD稳定期患者的临床疗效显著,能够明显减轻临床症状,提高肺活量,改善认知功能,且安全性较好。

Clinical Study of Bailing Capsules Combined with Doxofylline in the Treatment of Chronic Obstructive Pulmonary Disease in the Elderly at Stable Stage

OBJECTIVE:To probe into the clinical efficacy of Bailing capsules combined with doxofylline in the treatment of chronic obstructive pulmonary disease(COPD)in the elderly at stable stage.METHODS:Totally 200 patients with COPD admitted into Dujiangyan People’s Hospital from 2018 to 2019 were extracted to be divided into the control group(n=100)and the observation group(n=100)via the random number table.Patients in the control group were treated with doxofylline,while the observation group received Bailing capsules combined with doxofylline.Both groups were given continuous treatment for 8 weeks.Clinical efficacy was evaluated after treatment.Traditional Chinese medicine syndrome score,body mass index,obstruction,dyspnea,exercise(BODE)index and St.George’s respiratory questionnaire(SGOR)score,forced expiratory volume in one second(FEV1),forced vital capacity(FVC),serum monocyte chemoattractant protein-1(MCP-1),8-Hydroxy-deoxyguanylic acid(8-OHdG)levels before and after treatment in both groups were compared.The incidence of adverse drug reactions in both groups was observed.RESULTS:The total effective rate of the observation group was 95.00%(95/100),significantly higher than that of the control group 80.00%(80/100),the difference was statistically significant(χ²=10.286,P=0.001).Traditional Chinese medicine syndrome score,BODE index and SGOR score of two groups after treatment were significantly lower than those before treatment;traditional Chinese medicine syndrome score,BODE index and SGOR score of the observation group were significantly lower than those of the control group after treatment,and the differences were statistically significant(P<0.05).After treatment,FEV1 and FVC of two groups were significantly higher than those before treatment;FEV1 and FVC of the observation group were significantly higher than those of the control group,and the differences were statistically significant(P<0.05).The serum levels of MCP-1 and 8-OHdG in two groups were significantly lower than those before the treatment,and those in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse drug reactions in the observation group and control group were respectively 5.00%(5/100)and 6.00%(6/100),the difference was not statistically significant(P>0.05).CONCLUSIONS:The clinical efficacy of Bailing capsules combined with doxofylline in the treatment of COPD in the elderly at stable stage is significant,which can significantly reduce the clinical symptoms,increase the vital capacity,improve the cognitive function,and has good safety.