| 创伤后长链非编码RNA转移相关肺腺癌转录本1对机体调控机制的研究进展 |
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| 引用本文： | 张之飏,马娓,杨雪,李卫,何东梅,梁华平,杨霞. 创伤后长链非编码RNA转移相关肺腺癌转录本1对机体调控机制的研究进展[J]. 中华创伤杂志, 2021, 0(4): 379-384 |
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| 作者姓名： | 张之飏 马娓 杨雪 李卫 何东梅 梁华平 杨霞 |
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| 作者单位： | 陆军军医大学大坪医院战伤感染与特需药品研究室;东部战区陆军第71集团军 |
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| 基金项目： | 陆军军医大学科技创新能力提升专项(2019XQY18)。 |
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| 摘 要： | 创伤状态下机体处于一种十分复杂的病理生理状态,包括缺血缺氧,感染、组织坏死引起的炎症,以及代谢废物堆积等.转移相关肺腺癌转录本1(MALAT1)参与调控多种细胞行为,如增殖、凋亡、分化、迁移、上皮-间充质转化、自噬和形态维持等.在创伤状态下,MALAT1表达明显增高,在不同的损伤模型中,MALAT1的作用略有区别,具体...
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| 关 键 词： | 缺血 感染 长链非编码RNA |
Research progress in regulatory mechanism of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 after trauma |
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| Zhang Zhiyang,Ma Wei,Yang Xue,Li Wei,He Dongmei,Liang Huaping,Yang Xia. Research progress in regulatory mechanism of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 after trauma[J]. Chinese Journal of Traumatology, 2021, 0(4): 379-384 |
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| Authors: | Zhang Zhiyang Ma Wei Yang Xue Li Wei He Dongmei Liang Huaping Yang Xia |
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| Affiliation: | (Department of Wound Infection and Drug,Daping Hospital,Army Medical University,State Key Laboratory of Trauma,Burns and Combined Injury,Chongqing 400042,China;71st Group Army of the Eastern Theater Command,Huaian 223311,China) |
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| Abstract: | The body is in a very complex state under trouma,ineluding ischemia and hypoxia,inflammation cause ed by infetion and tissue necrosis and acumulation of metabolie the regulation waste.Metastasis associated lung ofa variety of cell behaviors,such.prienatime.apois,iferentiaion,migration,epithelial-menehymal tanstin.atoplngy and monphologial maintenance.Uinder trauma,the expression of MALATI is sifcanl icrawed In dfferent injury models,the role of MALATI is sighly diferent,and the seie mehanismn;is unknown.The authors summrie the regulatory efets of MALATI on the bodly under traumatic cond ditions from the biological charateristics r MALATI and is role in dfet injury moolels.so as to provid ide references for elinical control of disease prognosis. |
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| Keywords: | Ischemia Infection Long non-coding RNA |
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