| 45例肾病综合征肾小管间质病变病理和临床分析 |
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| 引用本文： | 林珊,屈会起. 45例肾病综合征肾小管间质病变病理和临床分析[J]. 天津医药, 2000, 28(8): 454-456 |
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| 作者姓名： | 林珊 屈会起 |
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| 作者单位： | 天津医科大学总医院肾科,300052 |
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| 摘 要： | 目的：探讨肾病综合征（ＮＳ）患者肾小管间质病变（ＴＩＬ）的发性情况。方法：观察４５例ＮＳ患者肾小管功能生化检查和肾活检病理切征ＴＩＬ。结果：原发性肾小球肾炎与狼疮性肾炎比较,尿Ｎ－乙酰－β－Ｄ氨基葡萄糖苷酶（ＮＡＧ）、尿重碳酸盐（ＨＣＯ３＾－）、可滴定酸（ＴＡ）、铵离子（ＮＨ４＾＋）、ＴＩＬ有显著性差异（Ｐ〈０．０５）。蛋白尿严重程度与尿ＮＡＧ（Ｐ〈０．０５）、尿渗透压（Ｐ〈０．０５）、ＴＩＬ（Ｐ
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| 关 键 词： | 肾病综合征 肾小管间质病变 病理 临床分析 |
Pathological and Clinical Analysis of Tubulointerstitial Lesions in 45 Cases with Nephrotic Syndrome |
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| LIN Shan,QU Huiqi. Pathological and Clinical Analysis of Tubulointerstitial Lesions in 45 Cases with Nephrotic Syndrome[J]. Tianjin Medical Journal, 2000, 28(8): 454-456 |
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| Authors: | LIN Shan QU Huiqi |
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| Affiliation: | LIN Shan,QU Huiqi Department of Nephrology,Tianjin medical University Hospital 300052 |
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| Abstract: | Objective:To study the occurrence of tubulointerstitial lesions (TIL) in nephrotic syndrome (NS). Methods:The bio-chemical tests about renal tubular function and the pathological changes of 45 cases with nephrotic syndrome were investi-gated. Results:Compared with patients with lupus nephritis, the patients with primary glomerular nephritis (PGN) had dif-ferent urine NAG,HCO_3 ~ - ,TA,NH_4~ and TIL (P<0.05) ;proteinuria of PGN was positively correlated to urine NAG (P <0.05),urine osmolar pressure (P<0.05) ,TA and NH_4~ (P<0.01) and TIL (P<0.01);compared with renal tubular functions of younger patients, those of older ones ( >35y) were prone to be injuried. Conclusion: Lupus nephritis causes more serious TIL than PGN;the increase of proteinuria and age may promote the development of TIL. |
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| Keywords: | nephrotic syndrome nephritis interstitial glomerulnephritis |
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