Expression of fatty acid synthase (FASN) in oral nevi and melanoma |
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| Authors: | de Andrade B A B León J E Carlos R Delgado-Azañero W Mosqueda-Taylor A Graner E de Almeida O P |
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| Affiliation: | 1. Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, S?o Paulo, Brazil;2. Pathology Section, Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, Guatemala;3. Oral Pathology and Medicine Department, Universidad Peruana Cayetano Heredia, Peru;4. Department of Health Care, Universidad Autónoma Metropolitana, Xochimilco, Mexico City, Mexico |
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| Abstract: | ![]()
Oral Diseases (2011) 17 , 808–812 Objective: The aim of this study was to determine the expression of fatty acid synthase (FASN) in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions. Materials and Methods: Expression of FASN was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas, in 10 cutaneous nevi and in 14 melanomas. Results: Fatty acid synthase was strongly expressed only in melanomas, either of the oral mucosa or cutaneous. On the other hand, most oral and cutaneous nevi were negative, with a few oral cases showing focal and weak expression. Conclusion: Fatty acid synthase is expressed in malignant melanocytes, and it can be a helpful marker to distinguish oral melanomas from oral melanocytic nevi. |
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| Keywords: | melanocytic nevi melanoma fatty acid synthase immunohistochemistry mouth |
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