Effect of isoproterenol on the isolated pregnant rat myometrium |
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| Authors: | K D Meisheri J H McNeill J M Marshall |
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| Affiliation: | 1. Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1W5;2. Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, U.S.A. |
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| Abstract: | ![]()
In pregnant rat myometrium, isoproterenol (10(-8) M) inhibited spontaneous contractions without causing hyperpolarization. Isoproterenol (10(-6) M) relaxed the depolarized muscle without affecting the membrane potential. The presence of 80 mM Na+ did not affect the degree of high-K+ depolarization. It was also without any influence on the effects of isoproterenol on the depolarized uterus. The results are consistent with the concept that hyperpolarization is not a prerequisite for beta-adrenoceptor induced relaxation of uterine smooth muscle. |
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| Keywords: | Membrane potential Uterine smooth muscle Isoproterenol |
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