结膜瓣遮盖联合睑裂缝合术予规范化药物干预治疗难治性角膜溃疡的疗效观察

[目的]探讨结膜瓣遮盖联合睑裂缝合术予规范化药物治疗难治性角膜溃疡的疗效。[方法]选取2007年5月至2013年7月本院住院并诊断为难治性角膜溃疡患者37例37眼，将其分为对照组17例17眼、观察组20例20眼，对照组实施结膜瓣遮盖联合睑裂缝合术及常规药物治疗，观察组实施结膜瓣遮盖联合睑裂缝合术及规范化药物治疗干预，术后6个月复诊观察疗效。[结果]观察组治愈18例（占90%），好转2例（占10%），对照组治愈9例（占52.9%），好转4例（占23.5%），无效4例（占23.5%），两组总疗效比较，差异有统计学意义（P＜0.05）。[结论]结膜瓣遮盖联合睑裂缝合术治疗难治性角膜溃疡，予规范化药物治疗干预，能明显提高手术疗效。

Therapeutic Observation of Conjunctiva Valve Combined with Tarsorrhaphy and Standardized Drug Intervention Treating Refractory Kera-tohelcosis

[Objective] To discuss the cure effect of conjunctiva valve combined with tarsorrhaphy and standardized medication on refractory keratohelcosis. [Method] Choose 37 cases with 37 eyes of the disease above, divide them into control group, n=17, and observation group, n=20; the control one take conjunctiva valve combined with tarsorrhaphy and routine medicine intervention; other group, standardized drug intervention instead of routine medicine. Observe the therapeutic effect after 6m. [Result] In observation group, 18 cases were cured（90%）, 2 better（10%）; for other group, they were 9（52.9%） and 4（23.5%） respectively, and 4 cases had no effect（23.5%）. Comparing both cure effects, the difference had statistical meaning. [Conclusion] The conjunctiva valve combined with tarsorrhaphy could markedly improve the cure effect if intervened with standardized drug.