| 4－甲基组胺对HL＿（60）细胞增殖、分化及c－myc基因表达的影响 |
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| 引用本文： | 刘建英,贺石林,蒋德昭. 4－甲基组胺对HL＿（60）细胞增殖、分化及c－myc基因表达的影响[J]. 中南大学学报(医学版), 1996, 0(5) |
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| 作者姓名： | 刘建英 贺石林 蒋德昭 |
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| 作者单位： | Research Laboratory of Blood Physiology，Hunan University |
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| 摘 要： | ![]()
用体外液体培养法，观察组胺Ｈ＿２受体激动剂４－ＭＮ对人类早幼粒白血病细胞系ＨＬ＿（６０）细胞的增殖和分化的影响。结果表明，１０￣（－３）～１０￣（－５）ｍｏｌ·Ｌ￣（－１）的４－ＭＨ能抑制ＨＬ＿（６０）细胞增殖，促进其分化。用胞浆ＲＮＡ斑点杂交技术检测到１０￣（－４）ｍｏｌ·Ｌ￣（－４）４－ＭＨ能降低ＨＬ＿（６０）细胞ｃ－ｍｙｃ基因的ｍＲＮＡ表达。
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| 关 键 词： | 组胺；激动剂；增殖抑制；诱导分化；致癌基因；HL＿（60） |
THE EFFECTS OF 4-MH ON THE PROLIFERATION,DIFFEKENTIATION AND C-myc ONCOGENE EXPRESSION OF HTE HL60 PROMYELOCYTIC LEUKEMIA CELLS |
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| Liu Jianying,Jiang Dezhao,He Shilin. THE EFFECTS OF 4-MH ON THE PROLIFERATION,DIFFEKENTIATION AND C-myc ONCOGENE EXPRESSION OF HTE HL60 PROMYELOCYTIC LEUKEMIA CELLS[J]. Journal of Central South University. Medical sciences, 1996, 0(5) |
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| Authors: | Liu Jianying Jiang Dezhao He Shilin |
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| Abstract: | ![]()
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| Keywords: | histamine agonist proliferative suppression induce differentiation oncogene HL60 |
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