34例原发性肺癌骨转移临床相关因素分析

目的]探讨原发性肺癌骨转移的临床相关因素。方法]34例原发性肺癌骨转移病例人组。骨转移率用Kaplan-Meier法计算。单因素分析用Logrank法，多因素用Cox回归模型。结果]从肺癌确诊开始到出现骨转移的中位时间为8个月。病理类型及淋巴结分期可影响骨转移发生率。结论]病理为腺鳞癌、淋巴结受累程度高的肺癌患者应进行积极的随访（尤其在确诊肺癌后的第一年）。

An Analysis of Clinical Related Factors with Bone Metastasis in 34 Cases with Primary Lung Cancer

Purpose ] To explore the clinical related factors with bone metastasis in primary lung cancer. Methods ] Thirty-four cases with bone metastasis from primary lung cancer were enrolled. The bone metastasis rates were obtained by Kaplan-Meier method, univariate analysis by Logrank, multivariate analysis by Cox regression. Results] The median time from the diagnosis of primary lung cancer to bone metastasis was 8 months. Both univariate analysis and multivariate analysis showed that the histologic type and Nstaging were independent clinical predictors. Conclusion] It is necessary to follow up closely in patient with adenosquamous carcinoma and high N-staging, especially in the first year of diagnosis with lung cancer.