| 异烟肼耐药突变katGS315T与日本大阪地区MDR－／XDR—TB患病率的相关性 |
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| 引用本文： | H.Ano,T.Matsumoto,T.Suetake,T.Nagai,Y.Tamura,I.Takamatsu,T.Iwasaki,H.Matsuoka,S. Sasada,S. Tetsumoto,I. Tsuyuguchi,Y. Kusunoki,T. Takashima,黄海荣[译].异烟肼耐药突变katGS315T与日本大阪地区MDR－／XDR—TB患病率的相关性[J].结核与肺部疾病杂志,2009,4(1):17-22. |
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| 作者姓名： | H.Ano T.Matsumoto T.Suetake T.Nagai Y.Tamura I.Takamatsu T.Iwasaki H.Matsuoka S. Sasada S. Tetsumoto I. Tsuyuguchi Y. Kusunoki T. Takashima 黄海荣[译] |
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| 作者单位： | [1]Department of Clinical Research and Development,Osaka Prefectural Medical Centre for Respiratory and AllergicDiseases, Osaka [2]Research and Development Laboratory, NIPRO Corporation, Osaka, Japan [3]不详, NIPRO Corporation, Osaka, Japan |
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| 基金项目： | This study was supported by a grant （H18-Shinkou-011） from the Ministry of Health, Labour and Welfare, Japan. |
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| 摘 要： | 目的：研究异烟肼耐药的结核分枝杆菌中katGS315T突变的发生情况，并探讨katGS315T突变与耐多药结核病（MDR—TB）患病率之间的相关性。设计：收集了从2001年到2004年间所有到大阪市呼吸与过敏性疾病医学中心就诊的新登记病人的临床分离株1655株，并进行了药物敏感性分析。对1655株菌株中的1629株（98．4％）应用插入序列（IS）6110-限制性片段长度多态性（RFLP）法进行了基因分型。对所有耐异烟肼的145个临床分离株，包括耐多药菌株，都进行了katGS315T的突变情况检测。结果：560（34．4％）株临床分离株有相同的RFLP图谱。在145个INH耐药的分离株中，18／48（37．5％）属于有katG$315T突变的RFLP簇，23／97（23．7％）没有发生此突变。在66个耐多药结核病病例中，18／29（62．1％）属于有katGS315T突变的RFLP簇，11／37（29．7％）没有发生此突变。在29例广泛耐药病例（XDR）中，17／21（80．9％）属于有katG$315T突变的RFLP簇，3／8（37．5％）没有发生此突变。结论：发生katGS315T突变的MDR-／XDR—TB分离株中应用IS—RFLP分析获得的成簇率非常高。我们的研究表明katG$315T突变与MDR—TB，尤其是XDR—TB的传播动力学高度相关。
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| 关 键 词： | MDR—TB XDR—TB 异烟肼耐药 katG IS6110-RFLP |
Relationship between the isoniazid-resistant mutation katGS315T and the prevalence of MDR-/XDR-TB in Osaka,Japan |
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| H.Ano,T.Matsumoto,T.Suetake,T.Nagai,Y.Tamura,I.Takamatsu,T.Iwasaki,H.Matsuoka,S.Sasada,S.Tetsumoto,I.Tsuyuguchi,Y.Kusunoki,T.Takashima.Relationship between the isoniazid-resistant mutation katGS315T and the prevalence of MDR-/XDR-TB in Osaka,Japan[J].The International Journal of Tuberculosis and Lung Disease,2009,4(1):17-22. |
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| Authors: | HAno TMatsumoto TSuetake TNagai YTamura ITakamatsu TIwasaki HMatsuoka SSasada STetsumoto ITsuyuguchi YKusunoki TTakashima |
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| Institution: | H.Ano (Department of Clinical Research and Development,Osaka Prefectural Medical Centre for Respiratory and Allergic Diseases,Osaka,Japan) ； T.Matsumoto (Department of Clinical Research and Development,Osaka Prefectural Medical Centre for Respiratory and Allergic Diseases,Osaka,Japan) ； T.Suetake (Research and Development Laboratory,NIPRO Corporation,Osaka,Japan) ； T.Nagai (Department of Clinical Research and Development,Osaka Prefectural Medical Centre for Respiratory and Allergic Diseases,Osaka,Japan) ； Y.Tamura (Department of Clinical Research and Development,Osaka Prefectural Medical Centre for Respiratory and Allergic Diseases,Osaka,Japan) ； I.Takamatsu (Department of Clinical Research and Development,Osaka Prefectural Medical Centre for Respiratory and Allergic Diseases,Osaka,Japan) ； T.Iwasaki (Department of Clinical Research and Development,Osaka Prefectural Medical Centre for Respiratory and Allergic Diseases,Osaka,Japan) ； H.Matsuoka (Department of Clinical Research and Development,Osaka Prefectural Medical Centre for Respiratory and Allergic Diseases,Osaka,Japan) ； S.Sasada (Department of Clinical Research and Development,Osaka Prefectural Medical Centre for Respiratory and Allergic Diseases,Osaka,Japan) ； S.Tetsumoto (Department of Clinical Research and Development,Osaka Prefectural Medical Centre for Respiratory and Allergic Diseases,Osaka,Japan) ； I.Tsuyuguchi (Department of Clinical Research and Development,Osaka Prefectural Medical Centre for Respiratory and Allergic Diseases,Osaka,Japan) ； Y.Kusunoki (Department of Clinical Research and Development,Osaka Prefectural Medical Centre for Respiratory and Allergic Diseases,Osaka,Japan) ； T.Takashima (Department of Clinical Research and Development,Osaka Prefectural Medical Centre for Respiratory and Allergic Diseases,Osaka,Japan) ； |
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