早产低质量儿暂时性低甲状腺素血症及危险因素

目的：了解早产低体质量儿暂时性低甲状腺素血症(THP)的发生情况，分析其危险因素。方法：对早产低体质量儿生后筛查甲状腺素(T4)，促甲状腺素(TSH)，计算THP的发生率，分析其发生的危险因素。结果：胎龄≤32周组THP的发生率为64％，明显高于33～36周组及≥37周组；出生体质量≤1500g组THP的发生率为80％，明显高于1501～2499g组及≥2500g组，差异具有统计学意义。经多因素Logistic回归分析示出生体质量、呼吸窘迫综合征、红细胞增多症，母亲妊娠高血压综合征及产前感染与THP发生相关。结论：胎龄≤32周或出生体质量≤1500g的早产低体质量儿THP发生率分别为64％及80％。新生儿低出生体质量、呼吸窘迫综合征及红细胞增多症是THP的危险因素。

Study on the Incidence and Risk Factors of Transient Hypothyroxinemia in Premature and Low-birth-weight Infants

Objective: To investigate the incidence of transient hypothyroxinemia (THP) in premature and low-birth-weight infants and analyze its risk factors. Methods: T4 and TSH were measured in premature and low-birth-weight infants.The incidence of THP was calculated and the risk factors were analyzed. Results: The incidence of THP in the group which gestational age was younger than 32 weeks (64%) was significantly higher than those which gestational age was equal to 33-36 weeks or longer than 37 weeks.The incidence of THP in the group which birth weight was less than 1 500 g (80%) were significantly higher than those in the groups which birth weight was equal to 1 501-2 499 g or greater than 2 500 g. There was a statistical significance of the differences. Neonatal birth weight, respiratory distress syndrome, polycythemia, pregnancy-induced hypertension and infection before delivery were correlative with THP by multivariate regression analysis. Conclusion: The incidence of THP were 64% and 80% respectively in infants which gestational age was younger than 32 weeks and birth weights less than 1 500 g. Neonatal low birth weights, respiratory distress syndrome and polycythemia are risk factors for THP.