韶关市老年HIV/AIDS人群首次CD4/CD8淋巴细胞计数分析

目的了解韶关市老年HIV/AIDS人群首次检测CD4/CD8淋巴细胞数量情况,获得其分布特征,为制定老年艾滋病防治策略提供科学依据。方法采集韶关市2008—2015年新发现的老年HIV/AIDS人群全血样本,用流式细胞仪进行CD4/CD8淋巴细胞检测,同时对感染人群的流行病学资料进行统计分析。结果本次纳入研究的共有HIV/AIDS 147例,其中男性患者95例,女性患者52例,年龄51~83岁,平均(68.51±17.58)岁,文化程度以初中及以下为主,占51.02%;本地户籍134例,占91.16%;感染途径以异性传播为主,占67.35%;其次为同性传播24例,占16.33%;CD4~+T淋巴细胞绝对值为3~1 254个/μL,平均(282.57±124.56)个/μL;不同性别、文化程度、地区范围、感染途径、性病史的CD4~+T淋巴细胞绝对值及CD4/CD8淋巴细胞比值差异无统计学意义(P0.05);不同年龄组之间的CD4~+T淋巴细胞绝对值及CD4/CD8淋巴细胞比值差异有统计学意义(t=6.354,P0.05)。结论韶关市老年人首次CD4~+T淋巴细胞检测结果普遍偏低,老年人艾滋病防治应加强早期监测和早期预防。

Analysis of first CD4/CD8 lymphocyte counts in elderly HIV/AIDS population in Shaoguan

Objective To understand the status and characteristics of the first CD4/CD8 lymphocyte counts in elderly HIV/AIDS population in Shaoguan City,so as to provide the evidence for formulating the AIDS prevention and control strategies in the elderly.Methods The blood samples of the newly discovered elderly HIV/AIDS persons were collected in Shaoguan City from 2008 to 2015,CD4/CD8 lymphocytes were detected by flow cytometry,and the epidemiological data was collected,and all the data were statistically analyzed.Results In this survey,there were 147 patients,including 95 male persons and 52 female persons,aged 51 to 83 years.The average age was (68.51± 17.58) years,the majority of them had junior high school educational level or below (51.02％).Most of them had the local household registration (134 cases,91.16％).The main infection route was heterosexual transmission (67.35％),followed by homosexual transmission (24 cases,16.33％).The minimum absolute value of CD4+T lymphocytes was 3/μL,the maximum was 1 254/μL,and the average was (282.57± 124.56)/ μL.There were no significant differences among the different genders,educational levels,areas,infection routes,and sexually transmitted disease histories in the CD4+T absolute value of lymphocytes and CD4/CD8 lymphocyte ratio (P＞0.05).However,there was a significant difference among the different age groups in the CD4+T absolute value of lymphocytes and CD4/CD8 lymphocyte ratio (t=6.354,P＜0.05).Conclusion The first CD4/CD8 lymphocyte counts in elderly HIV/AIDS population are generally low in Shaoguan City,and therefore,the prevention and control of HIV / AIDS should be strengthened.