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| 青蒿琥酯贴片的释放行为研究 | |
| 引用本文： | 侯海霞,周莉玲,李锐. 青蒿琥酯贴片的释放行为研究[J]. 中成药, 2001, 23(8): 547-550 |
| 作者姓名： | 侯海霞 周莉玲 李锐 |
| 作者单位： | 1. 广州中山医药有限公司,广东,广州,510080 2. 广州中医药大学,广东,广州,510405 |
| 基金项目： | 广东省自然科学基金课题(No.970224) |
| 摘 要： | 目的：研究青蒿琥酯贴片的释放规律。方法：制备青蒿琥酯贴片并测定青蒿琥酸的含量，通过体外经皮渗透实验的分析累积释放率及释放速率与释放时间的关系。结果：面积为10cm^2的贴片青蒿琥酯含量约为45mg，青蒿琥酯从贴片中的累积释放率随时间的延长呈增长趋势，但释放速率达一定值后趋于恒定。结论：青蒿琥酯从贴片中的释放规律符合Higuchi方程，并且已达持效性制剂的要求。 |
| 关 键 词： | 青蒿琥酯贴片 中成药 释放率 释放速率 Higuchi方程 持效性 抗疟药 含量 |
| 文章编号： | 1001-1528(2001)08-0547-03 |
| 修稿时间： | 2000-12-26 |
A Study on Releasing Rule of Artesunate TDD System |
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| HOU Hai xia ,ZHOU Li ling ,LI Rui. A Study on Releasing Rule of Artesunate TDD System[J]. Chinese Traditional Patent Medicine, 2001, 23(8): 547-550 | |
| Authors: | HOU Hai xia ZHOU Li ling LI Rui |
| Affiliation: | HOU Hai xia 1,ZHOU Li ling 2,LI Rui 2 |
| Abstract: | Objective: To study the releasing rule of Artesunate TDD s (ASTDDs). Methods: To prepare the ASTDDS and determine the content of artesunate, the transdermal experiments are used to study the relation between accumulative releasing ratio or releasing speed and releasing time. Results: The content of artesunate is about 45mg/10cm 2 and the accumulative releasing ratio increases with releasing time, but releasing speed is constant when the releasing speed reached some value. Conclusion: The releasing rule of ASTDDs conforms to Higuchi equation. The ASTDDs can come to durable effect. |
| Keywords: | Artesunate TDDs accumulative releasing ratio releasing speed Higuchi equation durable effect |
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