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| Increase of CD4^＋ CD25^＋ T cells in Smad3^-/- mice | |
| 引用本文： | Wang ZB,Cui YF,Liu YQ,Jin W,Xu H,Jiang ZJ,Lu YX,Zhang Y,Liu XL,Dong B. Increase of CD4^＋ CD25^＋ T cells in Smad3^-/- mice[J]. World journal of gastroenterology : WJG, 2006, 12(15): 2455-2458. DOI: 10.3748/wjg.v12.i15.2455 |
| 作者姓名： | Wang ZB Cui YF Liu YQ Jin W Xu H Jiang ZJ Lu YX Zhang Y Liu XL Dong B |
| 作者单位： | Zi-Bing Wang,Yu-Fang Cui,Wei Jin,Han Xu,Zhu-Jun Jiang,Ying Zhang,Xiao-Lan Liu,Bo Dong,Department of Immunology,Beijing Institute of Radiation Medicine,27 Taiping Road,Beijing 100850,China Yu-Qing Liu,Third Affiliated Hospital of Xinxiang Medical College,Xinxiang 453003,Henan Province,China Ya-Xin Lu,Institute of Biotechnology,Beijing 100071,China |
| 摘 要： | AIM: To investigate the changes of lymphocyte sub-populations, especially CD4 CD25 T regulatory cells in Smad3-/- mice. METHODS: Hematological changes and changes of lymphocyte subpopulations were detected in Smad3-/- mice using cell counter and flow cytometry, respectively, and compared to their littermate controls. RESULTS: The numbers of neutrophils and lymphocytes in peripheral blood were significantly increased in Smad3-/- mice compared to littermate controls. CD19 expressing cells in blood and spleen, and CDS T cells in thymus were all markedly decreased in Smad3-/- mice. More important, Smad3-/- mice had an increased population of CD4 CD25 T cells in peripheral lymphoid tissues, including thymus, spleen, and lymph nodes. CONCLUSION: These observations suggest that the changes of lymphocyte subpopulations might play a role in susceptibility to inflammation of Smad3-/- mice. |
| 关 键 词： | TGF-β signaling |
| 收稿时间： | 2005-10-29 |
Increase of CD4(+)CD25(+) T cells in Smad3(-/-) mice |
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| Wang Zi-Bing,Cui Yu-Fang,Liu Yu-Qing,Jin Wei,Xu Han,Jiang Zhu-Jun,Lu Ya-Xin,Zhang Ying,Liu Xiao-Lan,Dong Bo. Increase of CD4(+)CD25(+) T cells in Smad3(-/-) mice[J]. World journal of gastroenterology : WJG, 2006, 12(15): 2455-2458. DOI: 10.3748/wjg.v12.i15.2455 | |
| Authors: | Wang Zi-Bing Cui Yu-Fang Liu Yu-Qing Jin Wei Xu Han Jiang Zhu-Jun Lu Ya-Xin Zhang Ying Liu Xiao-Lan Dong Bo |
| Affiliation: | 1. Department of Immunology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China 2. Third Affiliated Hospital of Xinxiang Medical College, Xinxiang 453003, Henan Province, China 3. Institute of Biotechnology, Beijing 100071, China |
| Abstract: | AIM: To investigate the changes of lymphocyte sub-populations, especially CD4 CD25 T regulatory cells in Smad3-/- mice. METHODS: Hematological changes and changes of lymphocyte subpopulations were detected in Smad3-/- mice using cell counter and flow cytometry, respectively, and compared to their littermate controls. RESULTS: The numbers of neutrophils and lymphocytes in peripheral blood were significantly increased in Smad3-/- mice compared to littermate controls. CD19 expressing cells in blood and spleen, and CDS T cells in thymus were all markedly decreased in Smad3-/- mice. More important, Smad3-/- mice had an increased population of CD4 CD25 T cells in peripheral lymphoid tissues, including thymus, spleen, and lymph nodes. CONCLUSION: These observations suggest that the changes of lymphocyte subpopulations might play a role in susceptibility to inflammation of Smad3-/- mice. |
| Keywords: | CD4 CD25 T cells Lymphocyte subpopulation SlMlAD3 |
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