急性心肌梗死病人早期大剂量应用美托洛尔的疗效分析

目的:观察急性心肌梗死病人早期大剂量应用美托洛尔的疗效。方法:将173例急性心肌梗死病人随机双盲分为治疗组和对照组。治疗组在对照组常规治疗的基础上早期大剂量应用美托洛尔,比较两组心原性猝死、再发心梗、心原性休克、死亡率指标的变化。结果:急性心肌梗死病人早期大剂量应用美托洛尔治疗心原性猝死、梗死后再梗死发生率治疗组低于对照组(P<0.01),心原性休克发生率对照组低于治疗组(P<0.01)。两组总死亡率无显著性差异(P>0.05)。结论:急性心肌梗死病人早期大剂量应用美托洛尔治疗可减少心原性猝死、再发心梗的发生率,增加心原性休克的发生率。

Effect of early treatment with metoprolol in 173 acute myocardial infarction

Objective:To observe effect of giving metoprolol early in acute myocardial infarction(AMI).Methods:173 AMI cases were randomly divided into two groups,the treatment group was administered with metoprolol besides the conventional therapy administered in the placebo group.The two groups were compared in respects of the occurrences of cardiogenic sudden death and cardiogenic shock and relapse of myocardial infarction and death rate.Results:Compared with the Placebo group,the events of cardiogenic sudden death , cardiogenic shock and relapse of myocardial infarction were significantly decreased in the treatment group(P<0.01),but the rate of cardiogenic shock in the placebo group was lower than that in the treatment group(P<0.01).Conclusion:Early treat with metoprolol in AMI is useful to reduce the events of cardiogenic sudden death and relapse of myocardial infarction,but increase with cardiogenic shock.