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Fatal veno-occlusive disease of the liver following high dose chemotherapy,irradiation and bone marrow transplantation |
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| Authors: | William G. Woods Louis P. Dehner Mark E. Nesbit William Krivit Peter F. Coccia Norma K.C. Ramsay Tae H. Kim John H. Kersey |
| Affiliation: | Minneapolis, Minnesota, USA |
| Abstract: | In two patients fatal veno-occlusive disease of the liver developed after bone marrow transplantation for underlying malignancies. Both had received significant pretransplant chemotherapy, including cystosine arabinoside, and total body irradiation. The diagnosis of veno-occlusive disease should be considered in patients in whom hepatomegaly, ascites and deteriorating liver function tests develop after they have received cancer chemotherapy. |
| Keywords: | Requests for reprints should be addressed to Dr. William G. Woods Department of Pediatrics-Hematology Division Box 454 Mayo University of Minnesota Hospitals Minneapolis Minnesota 55455. |
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