强的松、N-乙酰半胱氨酸和卡托普利联合治疗特发性肺纤维化

目的:探讨强的松、N-乙酰半胱氨酸(NAC)和卡托普利(CPT)联合应用在特发性肺纤维化(IPF)治疗中的价值。方法:将33例IPF患者随机分为三组,对照组(12例)给予强的松常规治疗;联合治疗Ⅰ组(11例)在强的松基础上加用NAC;联合治疗Ⅱ组(10例)在强的松、NAC基础上加用CPT。治疗6个月后观察三组动脉血氧分压(PaO2),肺总量(TLC)、肺活量(VC)和一氧化碳弥散量(DLco)的变化。结果:在治疗6个月后,联合治疗Ⅱ组PaO2,TLC、VC和DLco占预计值的百分比显著高于对照组和联合治疗Ⅰ组(F=3.956~7.642,P均<0.05)。结论:强的松、NAC和CPT三药联合治疗IPF疗效佳,且安全易耐受。

Study on the Treatment of Idiopathic Pulmonary Fibrosis with Prednisone,N-acetylcysteine Combined Captopril

Objective To explore the clinical efficacy of prednisone,N-acetylcysteine(NAC) combined with Captopril(CPT) in the treament of idiopathic pulmonary fibrosis(IPF).Methods Thirty-three patients with IPF were randomly divided into three groups,prednisone was given in control group(n=12);prednisone and NAC were given in combined groupⅠ(n=11);prednisone,NAC combined with CPT were given in combined groupⅡ(n=10).The changes of arterial partial pressure of oxygen(PaO2),total lung capacity(TLC),vital capacity(VC) and diffusion capacity of carbon monoxide(DLco) in three groups were observed after administration for 6 months.Results The percentages that PaO2,TLC,VC,DLco accounting their predictive values in combined groupⅡ were significantly higher than those of combined groupⅠand control group after 6 months(F=3.956～7.642,allP<0.05).Conclusion Prednisone,NAC combined CPT is effective,safty and easy to tolerant in the treatment of IPF.