| 烯二炔类抗肿瘤抗生素力达霉素的作用机制研究进展 |
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| 引用本文： | 高瑞娟,李电东,甄永苏.烯二炔类抗肿瘤抗生素力达霉素的作用机制研究进展[J].中国新药杂志,2006,15(13):1039-1043. |
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| 作者姓名： | 高瑞娟 李电东 甄永苏 |
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| 作者单位： | 中国医学科学院,中国协和医科大学,医药生物技术研究所,北京,100050 |
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| 基金项目： | 高比容电子铝箔的研究开发与应用项目;国家重点基础研究发展计划(973计划);中国科学院资助项目 |
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| 摘 要： | 力达霉素（lidamycin,LDM）是一种用精原细胞法筛选得到的链霉菌Streptomyces globisporus C-1027代谢产物中分离获得的九元环烯二炔类抗肿瘤抗生素.LDM对体外试验培养癌细胞有极强的细胞毒作用,体内试验中对移植瘤疗效显著.现主要从断裂DNA、诱导细胞凋亡和裂亡、致细胞产生衰老样表型、抑制血管生成和改变肿瘤侵袭调节基因表达等方面阐述LDM强烈抗肿瘤作用的分子机制.
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| 关 键 词： | 力达霉素 DNA损伤 细胞凋亡 细胞裂亡 衰老样表型 血管生成 |
| 文章编号： | 1003-3734（2006）13-1039-05 |
| 修稿时间： | 2006-02-08 |
Study on mechanisms of action of enediyne antitumor antibiotic lidamycin |
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| GAO Rui-juan,LI Dian-dong,ZHEN Yong-su.Study on mechanisms of action of enediyne antitumor antibiotic lidamycin[J].Chinese Journal of New Drugs,2006,15(13):1039-1043. |
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| Authors: | GAO Rui-juan LI Dian-dong ZHEN Yong-su |
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| Institution: | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Lidamycin(LDM),one of nine-ring enediyne antitumor antibiotics,was isolated by spermatogonial assay from the metabolic products of Streptomyces globisporus C-1027,which was obtained from the soil samples at Qian-jiang County of Hubei Province,China.LDM exhibited potent cytotoxicity toward cultured carcinoma cells in vitro as well as significant therapeutic efficacy against transplantable tumors in vivo.This paper overviews the highly potent antitumor activities and mechanisms of LDM in re- spect of cutting DNA strands,inducing apoptosis and mitotic cell death,triggering senescence-like phe- notype,inhibiting angiogenesis and modulating the gene expression of invasive tumors. |
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| Keywords: | lidamycin DNA damage cell apoptosis mitotic cell death senescence-like phenotype angiogenesis |
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